{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:48:18Z","timestamp":1789937298852,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8336,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum creatine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U\/liter and a range of 59\u20131,327 U\/liter (male normal &lt;95 U\/liter, female normal &lt;59 U\/liter). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as having polymyositis and given high dose corticosteroids without clinical benefit, prior to the diagnosis of ALS. Such diagnostic confusion can be avoided by an awareness that CK levels cannot be used to reliably differentiate between ALS and primary muscle disease such as polymyositis.<\/jats:p>","DOI":"10.1002\/art.1780260212","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:53:43Z","timestamp":1171482823000},"page":"201-205","source":"Crossref","is-referenced-by-count":23,"title":["Elevation of creatine kinase in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"26","author":[{"given":"Thomas M.","family":"Harrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Bartleson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Ginsburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"325","article-title":"De la sclerose laterale amyotrophique","volume":"2","author":"Charcot JM","year":"1874","journal-title":"Prog Med Virol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(70)90373-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.9.964"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.24.9.834"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.7.697"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1001\/jama.1973.03230130024009","article-title":"Serum enzyme alterations in muscular disorders","volume":"226","author":"Munsat TL","year":"1973","journal-title":"JAMA"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197511000-00016"},{"key":"e_1_2_1_9_2","first-page":"599","article-title":"Die Serum CPK activital bei amyotropher lateral Sklerose (ALS) und anderen neurogenen musculatrophien unter Berucksichtigung differential Diagnosticher aspekte","volume":"12","author":"Koufen H","year":"1970","journal-title":"Nervenarzt"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1966.00470090093013"},{"key":"e_1_2_1_11_2","first-page":"246","volume-title":"Disturbance of oxidative phosphorylation in human dystrophic and denervated muscle, Muscle Diseases: Proceedings of an International Congress","author":"Ionasescu V","year":"1970"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/1841851a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.24.5.477"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90164-0"},{"key":"e_1_2_1_15_2","first-page":"397","article-title":"Exercise effect on creatine phosphokinase elevation in motor neuron disease","volume":"60","author":"Delisa JA","year":"1979","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_1_16_2","first-page":"25","volume-title":"System Disorders and Atrophies, Part II","author":"Norris FN","year":"1975"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-5-599"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780260212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780260212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:45:21Z","timestamp":1700696721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780260212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1002\/art.1780260212"],"URL":"https:\/\/doi.org\/10.1002\/art.1780260212","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}