{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:10:09Z","timestamp":1756995009427},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antilymphocyte antibodies (ALA) in rheumatoid arthritis (RA) have increased reactivity with phytohemagglutinin (PHA) activated lymphoblasts which are known to have increased expression of Ia antigen. The present experiments suggest that part of this reactivity represents an Ia specificity of ALA. Fifteen of 18 RA sera tested were able to inhibit the binding of monoclonal anti\u2010Ia antibodies as measured by a rosette method. RA sera did not inhibit the binding of other monoclonal antibodies: anti\u2010OKT3, anti\u2010OKT4, and anti\u2010OKT8. The ability of RA sera to inhibit the binding of anti\u2010Ia antibody was eliminated after absorption of the RA sera with an Ia positive human cell line (B35M) but not by an Ia negative line (MOLT4). Blocking of anti\u2010Ia binding was greater in the IgG fraction of the RA sera but also occurred in the IgM fraction. Experiments including ultracentrifugation, pepsin digestion of RA sera, and preincubation of lymphoblasts with aggregated IgG demonstrated that Fc binding by RA sera was not a factor. Both monoclonal anti\u2010Ia and anti\u2010Ia heteroantiserum also had increased reactivity with lymphoblast target cells. Pepsin digested Fab fragments of the anti\u2010Ia heteroantiserum were able to block the activity of cytotoxic RA serum. However, ALA cytotoxic to lymphoblasts did not correlate with anti\u2010Ia by rosette method. Ia\u2010specific ALA by rosette method was associated with donor variability but did not appear to be HLA\u2010DR restricted. Ia\u2010specific ALA did correlate with disease activity. These data suggest that anti\u2010Ia activity is present in RA sera and may play an immunoregulatory role in this disease.<\/jats:p>","DOI":"10.1002\/art.1780260406","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:15:29Z","timestamp":1171484129000},"page":"486-493","source":"Crossref","is-referenced-by-count":14,"title":["Ia specific antilymphocyte antibodies in rheumatoid arthritis"],"prefix":"10.1002","volume":"26","author":[{"given":"Robert P.","family":"Searles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Okudaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"issue":"1","key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0307-742X(21)00200-9","article-title":"Lymphocyte\u2010reactive antibodies in systemic lupus erythematosus","volume":"8","author":"Searles RP","year":"1982","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.2.122"},{"key":"e_1_2_1_4_2","first-page":"55","article-title":"Immunoglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells","volume":"12","author":"Munthe E","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105013"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140111"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190307"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.1.13"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190301"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197010012831403"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160312"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.4049\/jimmunol.122.2.614","article-title":"Anti\u2010\u03b22 microglobulin lymphocytotoxic autoantibodies in systemic lupus erythematosus","volume":"122","author":"Revillard JP","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230301"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110428"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180101"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(79)90155-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108303"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90441-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109396"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231108"},{"key":"e_1_2_1_21_2","first-page":"S1","article-title":"Proceedings of the ARA Conference on New Directions for Research in Systemic Lupus Erythematosus","volume":"21","year":"1978","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90183-5"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.2.246"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4049\/jimmunol.122.5.1780","article-title":"DRw antisera react with activated T cells","volume":"122","author":"DeWolf WC","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780070113"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"issue":"97","key":"e_1_2_1_27_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulates from human blood","volume":"29","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(80)90003-4"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.125.1.293"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1979.tb00786.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1976.tb00569.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.314668"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.4049\/jimmunol.124.3.1301","article-title":"A monoclonal antibody reactive with the human cytotoxic\/suppressor T cell subset previously defined by a heteroantiserum termed TH2","volume":"124","author":"Reinherz EL","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.124.4.1943"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.1.255"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/204998b0"},{"key":"e_1_2_1_37_2","first-page":"89S","article-title":"Two types of la positive T cell synthesis and exchange of Ia antigens","volume":"152","author":"Yu DT","year":"1980","journal-title":"J Exp Med"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(81)90480-9"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241106"},{"key":"e_1_2_1_40_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4049\/jimmunol.129.2.582","article-title":"Antibodies against Ia antigen in the sera of patients with systemic lupus erythematosus that block the binding of monoclonal anti\u2010Ia to Ia\u2010positive targets also inhibit the autologous mixed lymphocyte response","volume":"129","author":"Okudaira K","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160504"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4049\/jimmunol.127.2.726","article-title":"The role of adherent HLA\u2010DR+ mononuclear cells in autologous and allogeneic MLR","volume":"127","author":"Huber C","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_43_2","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.4049\/jimmunol.127.6.2438","article-title":"Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti\u2010Ia antibodies leads to an inhibition of cell proliferation","volume":"127","author":"Accolla RS","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00343720"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780260406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780260406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:57:51Z","timestamp":1700697471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780260406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1002\/art.1780260406"],"URL":"https:\/\/doi.org\/10.1002\/art.1780260406","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}