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Clinical findings included dry eyes in 38%, dry mouth in 32%, parotid enlargement in 4%, and an abnormal Schirmer'S test in 34%. Histologic changes in lip biopsies included lymphocytic infiltrates characteristic of Sj\u00f6gren'S syndrome in 17 individuals (29%). In 19 (33%) there was periglandular and intraglandular fibrosis (PSS\u2010fibrosis) without significant inflammation, an alteration characteristic of PSS per se. In the remaining 22 patients (38%) with PSS, no abnormality was found. Of those with PSS and Sj\u00f6gren'S syndrome, 53% had serum antibodies to SS\u2010A and\/or SS\u2010B, while only 1 patient with a normal biopsy had either of these antibodies. Anti\u2010SS\u2010A and anti\u2010SS\u2010B were not detected in patients with glandular fibrosis alone. The mortality rate of the PSS\u2010fibrosis group was higher due to a variety of severe internal manifestations related to PSS. Antibodies to SS\u2010A and SS\u2010B are useful serologic markers of the presence of Sj\u00f6gren'S syndrome in patients with PSS.<\/jats:p>","DOI":"10.1002\/art.1780260408","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:15:29Z","timestamp":1171484129000},"page":"500-508","source":"Crossref","is-referenced-by-count":55,"title":["Clinical and serologic study of sj\u00f6gren's syndrome in patients with progressive systemic sclerosis"],"prefix":"10.1002","volume":"26","author":[{"suffix":"JR.","given":"Thaddeus A.","family":"Osial","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa L.","family":"Whiteside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Buckingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurmukh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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