{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:58:49Z","timestamp":1790456329749,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgG was purified from 91 serum samples obtained from patients with systemic rheumatic diseases and examined for the presence of antinuclear antibodies reactive with small ribonucleoprotein (RNP) complexes. Antibody specificity was determined by autoradiographic detection of <jats:sup>32<\/jats:sup>P labeled RNA which had been separated by polyacrylamide gel electrophoresis. This RNA was extracted from immune complexes formed by adding purified IgG to a homogenate of <jats:sup>32<\/jats:sup>P labeled HeLa cells. Anti\u2010RNP antibodies were detected in 70% of these samples. Specific antibodies detected were anti\u2010(U1)\u2010RNP (35%), anti\u2010Sm (30%), anti\u2010Ro (24%), and anti\u2010La (10%). Other antibodies (9%) were reactive with structures containing 5S and 5.8S RNA or 4S RNA. There was a significant relationship between the presence of anti\u2010RNP antibodies in patients with systemic lupus erythematosus (SLE) (78%) as opposed to their presence in patients with non\u2010SLE rheumatic disorders (45%). However, taken individually, anti\u2010Ro was the only antibody whose presence in SLE patients (30%) was significantly greater than its presence in non\u2010SLE patients (5%). Vasculitis was the only clinical manifestation found to correlate with the presence of a particular antibody, anti\u2010(U1)RNP. There is some suggestion of a racial distribution of antibody types.<\/jats:p>","DOI":"10.1002\/art.1780260409","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:15:29Z","timestamp":1171484129000},"page":"509-515","source":"Crossref","is-referenced-by-count":21,"title":["Clinical characteristics of patients with rheumatic disorders who possess antibodies against ribonucleoprotein particles"],"prefix":"10.1002","volume":"26","author":[{"given":"Gerald G.","family":"Williamson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Pennebaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/283220a0"},{"key":"e_1_2_1_3_2","first-page":"31","article-title":"Small RNA's in hnRNP fibrils and their possible function in splicing","volume":"7","author":"Gallinaro H","year":"1981","journal-title":"Mol Biol"},{"key":"e_1_2_1_4_2","first-page":"41","article-title":"Particles containing small molecular weight nuclear RNA's (snRNP's)","volume":"7","author":"Liautard J","year":"1981","journal-title":"Mol Biol"},{"key":"e_1_2_1_5_2","first-page":"107","article-title":"Nuclear ribonucleoprotein particles from adenovirus infected HeLa cells","volume":"7","author":"Blanchard JM","year":"1981","journal-title":"Mol Biol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01732762"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.96.3.464"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.102.1.117"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170413"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.11.5495"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.4049\/jimmunol.107.5.1281","article-title":"Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera","volume":"107","author":"Mattioli M","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6164096"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190309"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00524a001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.1.626"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108007"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108637"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220719"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196803072781004"},{"key":"e_1_2_1_21_2","first-page":"131","article-title":"Substantial purification of the Sm antigen and association of high titer antibody of Sm with a clinical subset of systemic lupus erythematosus","volume":"20","author":"Powers R","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241003"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12530348"},{"key":"e_1_2_1_24_2","first-page":"19","volume-title":"Connective tissue diseases, Primer on the Rheumatic Diseases","author":"Rodnan GP","year":"1973"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-1-55"},{"key":"e_1_2_1_26_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_27_2","unstructured":"Bio\u2010Rad Laboratories Bulletin 1062 Richmond California"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196909252811304"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00688a010"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00858a033"},{"key":"e_1_2_1_31_2","first-page":"218","volume-title":"Statistical Package for the Social Sciences","author":"Nie NH","year":"1975"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.5.2737"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230304"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","unstructured":"ReichlinM MattioliM:Correlation of a precipitin reaction to an RNA protein antigen and a low prevalence of nephritis in patients with systemic lupus erythematosus. 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