{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:13:22Z","timestamp":1759335202806},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When HeLa cells were used as the substrate for detection by the indirect immunofluorescence method, antinuclear antibodies were demonstrated in 16 of 22 (72.7%) sera from patients with localized scleroderma. When mouse kidney sections were used, the positive rate for antinuclear antibodies was 50% (11 of 22). In the 3 subgroups of localized scleroderma, frequencies of anti\u2010nuclear antibodies on HeLa cells were as follows: morphea, 50% (2 of 4), generalized morphea, 100% (6 of 6), linear scleroderma, 67% (8 of 12). Antibodies to centromere, Scl\u201070, nuclear RNP, Sm, and SS\u2010B antigens were not detected in any patient with localized scleroderma. The high frequency of antinuclear antibodies in localized scleroderma sera suggests that localized scleroderma is a disease which, though different from diffuse scleroderma, also involves an immunologic abnormality.<\/jats:p>","DOI":"10.1002\/art.1780260506","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:13:11Z","timestamp":1171483991000},"page":"612-616","source":"Crossref","is-referenced-by-count":102,"title":["Antinuclear Antibodies in Localized Scleroderma"],"prefix":"10.1002","volume":"26","author":[{"given":"Kazuhiko","family":"Takehara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuoki","family":"Moroi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Nakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580150005001"},{"key":"e_1_2_1_3_2","first-page":"44","article-title":"Scleroderma, especially involving generalized morphea","volume":"31","author":"Tanioku K","year":"1973","journal-title":"Jpn Clin"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/archderm.1980.01640250071020","article-title":"Circumscribed scleroderma with immunologic evidence of systemic lupus erythematosus","volume":"116","author":"Mitchell AJ","year":"1980","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1980.tb00283.x"},{"key":"e_1_2_1_6_2","first-page":"133","article-title":"Eosinophilia and serologic abnormalities in linear localized scleroderma (abstract)","volume":"20","author":"Rodnan GP","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/archderm.1967.01610030068012","article-title":"The diagnostic value of an antinuclear antibody test in clinical dermatology","volume":"96","author":"Rowell NR","year":"1967","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.99.5.611"},{"key":"e_1_2_1_9_2","first-page":"536","article-title":"Das Verhalten der antinukle\u00e4ren Faktoren bei Sklerodermie","volume":"161","author":"Barthelmes H","year":"1975","journal-title":"Dermatol Monatsschr"},{"key":"e_1_2_1_10_2","first-page":"526","article-title":"Serologic abnormalities and their significance in localized scleroderma (abstract)","volume":"18","author":"Scarola JA","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_11_2","first-page":"369","volume-title":"Immunopathology of the Skin","author":"Jablonska S","year":"1979"},{"key":"e_1_2_1_12_2","first-page":"859","article-title":"Localized scleroderma and PSS specific antibody to Og antigen","volume":"91","author":"Nishikawa T","year":"1981","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(72)90013-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190309"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.5.438"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1976.tb03030.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/jcm.2.1.42-45.1975","article-title":"Evaluation of cellular substrates for antinuclear antibody determination","volume":"5","author":"Hohan N","year":"1975","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1627"}],"container-title":["Arthritis &amp; 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