{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:27:02Z","timestamp":1760264822043},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tight\u2010skin (TSK) mouse has cutaneous changes similar to those found in the skin of patients with progressive systemic sclerosis (PSS). Previous studies have shown that both have common abnormalities in skin thickness, dry weight, and hydroxyproline content. In this study, glycosaminoglycans (GAGs), major components of the ground substance, were quantitated in skins from TSK mice and compared with age\u2010matched normal mice. Biochemical studies included determinations of hexosamines, uronic acids, and total GAGs by cetylpyridinium chloride precipitation. Dry weights and water\u2010fat content of skin biopsy specimens from TSK mice were also compared with those of normal mice. Hexosamine, uronic acid, total GAGs, and dry weight were increased in TSK mouse skin when compared with normal mouse skin. The water\u2010fat content did not differ significantly. These findings were similar to those known to occur in PSS skin, further suggesting that the TSK mouse might serve as an animal model for the skin changes found in PSS patients.<\/jats:p>","DOI":"10.1002\/art.1780260512","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:13:11Z","timestamp":1171483991000},"page":"653-657","source":"Crossref","is-referenced-by-count":17,"title":["Glycosaminoglycan Content in Skin of the Tight\u2010Skin Mouse"],"prefix":"10.1002","volume":"26","author":[{"given":"Stephen C.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Zuckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12543353"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-86-21203"},{"key":"e_1_2_1_4_2","first-page":"401","article-title":"Connective tissue in scleroderma","volume":"51","author":"Uitto J","year":"1971","journal-title":"Acta Derm Venereol (Stockholm)"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12538919"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(62)90095-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66055-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0271824"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110249.ch4"},{"key":"e_1_2_1_10_2","first-page":"493","article-title":"Tight\u2010skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton","volume":"82","author":"Green MC","year":"1976","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archderm.1972.01620040031005","article-title":"Alteration of subcutaneous tissue in systemic scleroderma","volume":"105","author":"Fleischmajer R","year":"1972","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12535041"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210404"},{"key":"e_1_2_1_14_2","unstructured":"OsbornTG BauerNE RossSC MooreTL ZucknerJ:Characterization of the TSK mouse as a scleroderma model. Submitted for publication"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220205"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780260512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780260512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:08:32Z","timestamp":1700698112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780260512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983,5]]}},"alternative-id":["10.1002\/art.1780260512"],"URL":"https:\/\/doi.org\/10.1002\/art.1780260512","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}