{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:12:14Z","timestamp":1761945134759,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8216,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum beta\u20102\u2010microglobulin (\u03b2<jats:sub>2<\/jats:sub>m) levels, incidence and levels of anti\u2010\u03b2<jats:sub>2<\/jats:sub>m autoantibodies, and quantity of circulating macromolecular complexes containing \u03b2<jats:sub>2<\/jats:sub>m were studied in patients with Felty's syndrome (FS), joint\u2010restricted rheumatoid arthritis (RA), and healthy controls. The serum \u03b2<jats:sub>2<\/jats:sub>m concentrations detected in the FS group (6.95 \u00b1 2.9 mg\/liter) greatly exceeded those of the RA group (3.4 \u00b1 1.2 mg\/liter) and the control group (1.42 \u00b1 0.69 mg\/liter). Autoantibodies to \u03b2<jats:sub>2<\/jats:sub>m were frequent in the FS group. Circulating complexes containing \u03b2<jats:sub>2<\/jats:sub>m, prepared by precipitation in 3% polyethylene glycol, were detected in 65% of FS and 35% of RA patients. In the majority of these cases the solid\u2010phase Clq purified immune complexes also contained \u03b2m. Detection of anti\u2010\u03b2<jats:sub>2<\/jats:sub>m antibodies in a significant part of complexes containing \u03b2<jats:sub>2<\/jats:sub>m suggests the presence of specific immune complexes in this fraction of FS and RA patients.<\/jats:p>","DOI":"10.1002\/art.1780260604","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:53Z","timestamp":1171483973000},"page":"721-727","source":"Crossref","is-referenced-by-count":11,"title":["High Serum Beta\u20102\u2010Microglobulin Levels and Circulating Immune Complexes Containing \u03b2m AND Anti\u2010\u03b2m Antibodies in Felty's Syndrome"],"prefix":"10.1002","volume":"26","author":[{"given":"Andr\u00e1S","family":"Falus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Wiik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Permin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Brandslund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven\u2010Erik","family":"Svehag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb05457.x"},{"key":"e_1_2_1_3_2","first-page":"245","article-title":"The prevalence of IgE antinuclear antibodies in rheumatoid arthritis and systemic lupus erythematosus","volume":"86","author":"Permin H","year":"1978","journal-title":"Acta Pathol Microbiol Scand [C]"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220702"},{"key":"e_1_2_1_5_2","first-page":"413","article-title":"Phagocytosis of immune complexes by polymorphonuclear leukocytes in patients with Felty's syndrome","volume":"28","author":"Hurd ER","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/08820137209022891","article-title":"Chemotaxis of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and Felty's syndrome","volume":"1","author":"Zifkovic M","year":"1972","journal-title":"Immunol Commun"},{"key":"e_1_2_1_7_2","first-page":"183","article-title":"Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty's syndrome","volume":"88","author":"Gupta RC","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.328"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190532"},{"key":"e_1_2_1_10_2","first-page":"366","article-title":"Cerebrospinal fluid \u03b22microglobulin in neurological disorders","volume":"57","author":"Teuhunen R","year":"1978","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747809098844"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908233010827"},{"key":"e_1_2_1_13_2","first-page":"535","article-title":"Antibodies to \u03b22microglobulin in the sera of patients with systemic lupus erythematosus","volume":"33","author":"Ooi BS","year":"1977","journal-title":"Immunology"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.4049\/jimmunol.122.2.614","article-title":"Anti\u2010\u03b22microglobulin lymphocytotoxic autoantibodies in systemic lupus erythematosus","volume":"122","author":"Revillard JP","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.4.409"},{"key":"e_1_2_1_16_2","first-page":"865","article-title":"Use of the ELISA to screen for anti\u2010thymocyte and anti\u2010\u03b22microglobulin antibodies in leprosy and SLE","volume":"41","author":"Bahr GM","year":"1980","journal-title":"Immunology"},{"key":"e_1_2_1_17_2","unstructured":"RevillardJP BeorchiaS VincentC TrepoC:Serum \u03b22\u2010microglobulin (\u03b22m) levels and \u03b22m\u2010binding antibodies in liver diseases (abstract). Fed Proc 38.1224 1979"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1981.tb00107.x"},{"key":"e_1_2_1_19_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_20_2","first-page":"551","volume-title":"Detection and quantitation of immune complexes with a rapid polyethylene glycol precipitation method (PEG\u2010CC), Methods in Enzymology: Immunochemical Techniques","author":"Brandslund I","year":"1981"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009091520"},{"key":"e_1_2_1_22_2","first-page":"443","volume-title":"\u03b22microglobulin, The Plasma Proteins","author":"Poulik MD","year":"1975"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.4049\/jimmunol.114.3.997","article-title":"Studies on the cytophilic properties of human \u03b22microglobulin","volume":"144","author":"Andersson CL","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00615a029"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250403"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(77)90399-0"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.89.3.706"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830091210"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1980.tb00057.x"},{"key":"e_1_2_1_30_2","first-page":"647","article-title":"Rheumatoid factors bind \u03b22microglobulin: detection of \u03b22microglobulin complexes in rheumatoid arthritis","volume":"27","author":"Falus A","year":"1979","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197702000-00021"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-5-623"},{"key":"e_1_2_1_33_2","first-page":"307","article-title":"Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome","volume":"39","author":"Starkebaum G","year":"1980","journal-title":"Clin Exp Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780260604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780260604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:26:17Z","timestamp":1700699177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780260604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1002\/art.1780260604"],"URL":"https:\/\/doi.org\/10.1002\/art.1780260604","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"type":"print","value":"0004-3591"},{"type":"electronic","value":"1529-0131"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}