{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:52:51Z","timestamp":1789905171878,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8216,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe 3 children with Lowe's syndrome who developed joint manifestations\u2014\u2010a previously rarely recognized feature. Two children had swelling and contractures of large and small joints; the third child had a small joint effusion and hypermobile joints. None of them had antinuclear antibody or rheumatoid factor; synovial effusions and biopsies showed no evidence of inflammatory cell infiltration. By light microscopy, profuse fibrous tissue and sparse synovial lining cells were found. Electron microscopy of the synovium of 2 patients showed large amounts of normal appearing collagen, unidentified thin fibrils, and focal profuse granular and fibrillar basement membrane\u2010like material around small vessels, similar to findings described in other tissues in this syndrome. Whether these clinical and pathologic findings are results of the still incompletely understood basic metabolic defect or not, they should be recognized as features that may be seen in patients with Lowe's syndrome.<\/jats:p>","DOI":"10.1002\/art.1780260605","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:53Z","timestamp":1171483973000},"page":"728-735","source":"Crossref","is-referenced-by-count":20,"title":["Arthropathy of Lowe's (Oculocerebrorenal) Syndrome"],"prefix":"10.1002","volume":"26","author":[{"given":"Balu H.","family":"Athreya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ralph","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry D.","family":"Getz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer Borden,","family":"Iv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillus L.","family":"Witzleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"164","article-title":"Organic aciduria, decreased renal ammonia production, hydroph\u2010thalmos and mental retardation: a clinical entity","volume":"83","author":"Lowe CU","year":"1952","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Clinicopathological studies of oculocerebrorenal syndrome of Lowe, Terrey and MacLachlan","volume":"24","author":"Martin MA","year":"1980","journal-title":"J Ment Defic Res"},{"key":"e_1_2_1_4_2","unstructured":"KierasFJ HouckGEJr FrenchJH WisniewskiK:Studies on the urinary glycosaminoglycans excreted in patients with Lowe's syndrome (abstract) Annual Meeting of the Society for Complex Carbohydrates. Philadelphia 1981"},{"key":"e_1_2_1_5_2","first-page":"150","volume-title":"Major Problems in Clinical Pediatrics","author":"Harrison HE","year":"1979"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1976.tb03652.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90163-0"},{"issue":"3","key":"e_1_2_1_8_2","first-page":"249","article-title":"Lowe's syndrome: pathological studies of four cases","volume":"7","author":"Rutsaert J","year":"1972","journal-title":"Pathol Europ"},{"key":"e_1_2_1_9_2","first-page":"221","article-title":"Renal changes in oculocerebrorenal syndrome of Lowe","volume":"89","author":"Ores RO","year":"1970","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1968.02100010147003"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90367-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"10313","DOI":"10.1016\/S0021-9258(19)68620-5","article-title":"Glycosaminoglycan synthesis by cultured skin fibroblasts from a patient with Lowe's syndrome","volume":"256","author":"Fukui S","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(81)80064-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12519993"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210405"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780260605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780260605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:26:24Z","timestamp":1700699184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780260605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1002\/art.1780260605"],"URL":"https:\/\/doi.org\/10.1002\/art.1780260605","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}