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Patients with anti\u2010Sm were more likely to have renal disease and antibodies to double\u2010stranded DNA, single\u2010stranded DNA, and nuclear protein than were patients with anti\u2010RNP. No clinical associations were found for anti\u2010RNP. Although most of the patients with antibodies to Sm, RNP, or both had systemic lupus erythematosus, some had other diagnoses, including cutaneous lupus, drug\u2010induced lupus, rheumatoid arthritis, juvenile arthritis, mixed connective tissue disease, Raynaud's disease, progressive systemic sclerosis, miscellaneous rheumatic and non\u2010rheumatic diseases, and undifferentiated connective tissue disease syndromes. These findings suggest that these antibodies may be associated with some diseases, but are not disease\u2010specific.<\/jats:p>","DOI":"10.1002\/art.1780260705","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:52Z","timestamp":1171483972000},"page":"848-853","source":"Crossref","is-referenced-by-count":64,"title":["Antibodies to SM and RNP"],"prefix":"10.1002","volume":"26","author":[{"given":"Ellen Field","family":"Munves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Schur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"446","article-title":"Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus","volume":"96","author":"Tan EM","year":"1966","journal-title":"J Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.4049\/jimmunol.107.5.1281","article-title":"Characterization of a soluble nuclear ribonucleoprotein antigen reactive with systemic lupus erythematosus sera","volume":"187","author":"Mattioli M","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.5.442"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747809095661"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197611182952101"},{"key":"e_1_2_1_8_2","first-page":"769","article-title":"Ribonucleoprotein antibodies: frequency and clinical significance in systemic lupus erythematosus, scleroderma, and mixed connective tissue disease","volume":"82","author":"Parker MD","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(80)90013-X"},{"key":"e_1_2_1_10_2","first-page":"S181","article-title":"Mixed connective tissue disease: current concepts","volume":"20","author":"Sharp GC","year":"1977","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_11_2","first-page":"587","article-title":"MCTD: mixed connective tissue disease\u2014a subset with sequential clinical and laboratory features","volume":"8","author":"Grant KD","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197701000-00002"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-4-464"},{"key":"e_1_2_1_14_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_15_2","first-page":"691","volume-title":"Systemic lupus erythematosus: clinical and laboratory aspects. 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