{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:28:56Z","timestamp":1791858536935,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8186,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood lymphocytes (PBL) producing IgA, IgM, and IgG, both spontaneously and after pokeweed mitogen stimulation in cell culture, were determined by a protein A hemolytic plaque assay in 20 children with active Henoch\u2010Sch\u00f6nlein purpura (HSP), 42 with inactive disease, 22 normal controls of the same ages, and 18 children with upper respiratory tract infections (URTI). The geometric mean of circulating IgA\u2010producing cells in active HSP (1,016 <jats:styled-content>\\documentclass{article}\\pagestyle{empty}\\begin{document}$\\[\\begin{array}{l} \\times \\\\ \\div \\\\ \\end{array}\\] $\\end{document}<\/jats:styled-content>\n1.55 cells\/10<jats:sup>6<\/jats:sup> PBL) was increased when compared with the group with inactive disease (<jats:italic>P<\/jats:italic> &lt; 0.001), normal controls (<jats:italic>P<\/jats:italic> &lt; 0.001), and children with URTI (542 <jats:styled-content>\\documentclass{article}\\pagestyle{empty}\\begin{document}$ \\[\\begin{array}{l} \\times \\\\ \\div \\\\ \\end{array}\\] $\\end{document}<\/jats:styled-content>\n2.03 cells\/10<jats:sup>6<\/jats:sup> PBL, <jats:italic>P<\/jats:italic> &lt; 0.05). The number of circulating IgM\u2010producing cells was slightly increased in active HSP (260 <jats:styled-content>\\documentclass{article}\\pagestyle{empty}\\begin{document}$ \\[ \\begin{array}{l} \\times \\\\ \\div \\\\ \\end{array}\\] $\\end{document}<\/jats:styled-content>\n2.65 cells\/10<jats:sup>6<\/jats:sup> PBL) and URTI (256 <jats:styled-content>\\documentclass{article}\\pagestyle{empty}\\begin{document}$ \\[\\begin{array}{l} \\times \\\\ \\div \\\\ \\end{array}\\] $\\end{document}<\/jats:styled-content>\n3.16 cells\/10<jats:sup>6<\/jats:sup> PBL). Both values were higher than those found in the group with inactive disease (113 <jats:styled-content>\\documentclass{article}\\pagestyle{empty}\\begin{document}$ \\[\\begin{array}{l} \\times \\\\ \\div \\\\ \\end{array}\\] $\\end{document}<\/jats:styled-content>\n2.26 cells\/10<jats:sup>6<\/jats:sup> PBL, <jats:italic>P<\/jats:italic> &lt; 0.01). There were no significant differences among the 4 groups in the number of circulating IgG\u2010producing cells. The number of cells producing each type of immunoglobulin after in vitro stimulation with pokeweed mitogen was similar in patients with active HSP, normal controls, and the group with inactive disease. These data demonstrate a selective increase in the number of circulating IgA\u2010producing cells only during disease activity, and add further support to a possible pathogenic role of this immunoglobulin in HSP.<\/jats:p>","DOI":"10.1002\/art.1780260706","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:52Z","timestamp":1171483972000},"page":"854-860","source":"Crossref","is-referenced-by-count":31,"title":["Increased IgA\u2010producing cells in the blood of patients with active henoch\u2010sch\u00f6nlein purpura"],"prefix":"10.1002","volume":"26","author":[{"given":"B.","family":"Casanueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rodriguez\u2010Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garcia\u2010Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)32782-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/archderm.1976.01630260039011","article-title":"Leucocytoclastic vasculitis","volume":"112","author":"Sams WM","year":"1976","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.11.822"},{"key":"e_1_2_1_5_2","first-page":"981","article-title":"Dermal and glomerular deposition of IgA in anaphylactoid purpura","volume":"131","author":"Giangiacome J","year":"1977","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1977.tb01648.x"},{"key":"e_1_2_1_7_2","first-page":"495","article-title":"Primary IgA glomerulonephritis and Schonlein\u2010Henoch purpura nephritis: clinicopathological and immunohistological characteristics","volume":"188","author":"Nakamoto Y","year":"1978","journal-title":"Q J Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5875.326"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6080.163"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92505-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(80)80011-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012043032306"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109998"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4049\/jimmunol.128.1.486","article-title":"Similar disturbances in B cell activity and regulatory T cell function in Henoch\u2010Schonlein purpura and systemic lupus erythematosus","volume":"128","author":"Beale MG","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulo\u2010cytes from human blood: isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g","volume":"21","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest (suppl 97)"},{"key":"e_1_2_1_16_2","first-page":"181","article-title":"Pokeweed mitogen induced differentiation of human B cells: evaluation by a protein A haemolytic plaque assay","volume":"38","author":"Hammarstrom L","year":"1979","journal-title":"Immunology"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(81)90190-3"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(78)90207-1"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4049\/jimmunol.118.4.1480","article-title":"Detection of plaque\u2010forming cells in the peripheral blood of actively immunized humans","volume":"188","author":"Thomson PD","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","first-page":"76","article-title":"Circulating and pokeweed mitogen\u2010induced immunoglobulin secreting cells in systemic lupus erythematosus","volume":"35","author":"Ginsburg WW","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_21_2","first-page":"1892","article-title":"Evidence for a commom mucosal immunologic system. 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