{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:48:47Z","timestamp":1769197727385,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8186,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent reports on the Pond\u2010Nuki model of osteo\u2010arthritis in the dog have provided evidence for partial disruption of the collagen network. The possibility of collagenase involvement in these localized changes was studied. Animals were killed 2, 4, 8, and 12 weeks after surgery. The left knee served as a sham\u2010operated control. Cartilages from femoral condyles were processed for light and electron microscopy and assayed for collagenolytic activity by a direct tissue assay, based on the measurement of digestion of endogenous cartilage collagen. Animals killed at 2 and 4 weeks showed fibrillation and mild erosion of femoral condyles, which usually progressed to ulceration by 8 and 12 weeks. Electron microscopy demonstrated fiber disruption of the midzone perilacunar collagen as early as 2 weeks after the operation. Total collagenolytic activity, measured after activation by aminophenylmercuric acetate, was significantly higher in diseased cartilage than in controls of 2, 4, and 8 weeks; the peak value was at 4 weeks. Collagenase was shown, by its specific action on type I collagen, to be present at 2 and 4 weeks; however, other metallo\u2010proteases may also contribute to the digestion. The correlation between increased collagenolytic activity and the early osteoarthritic changes in cartilage suggests a role of this enzyme activity in the disease process.<\/jats:p>","DOI":"10.1002\/art.1780260708","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:52Z","timestamp":1171483972000},"page":"866-874","source":"Crossref","is-referenced-by-count":98,"title":["Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the pond\u2010nuki dog model of osteoarthritis"],"prefix":"10.1002","volume":"26","author":[{"given":"Jean\u2010Pierre","family":"Pelletier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Martel\u2010Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy D.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latifa","family":"Ghandur\u2010Mnaymneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J.","family":"Frederick Woessner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.4.387"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1302\/0301-620X.59B1.576611","article-title":"An experimental model of osteoarthritis: early morphological and biochemical changes","volume":"59","author":"McDevitt CA","year":"1977","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.58B1.131804"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(81)90030-5"},{"key":"e_1_2_1_6_2","first-page":"215","article-title":"Dog cartilage in osteoarthritis: matrix and mechanical properties","volume":"5","author":"Altman RD","year":"1980","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_7_2","first-page":"103","article-title":"Dog cartilage in osteoarthritis: biochemical and biomechanical properties","volume":"4","author":"Riskin WG","year":"1979","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_8_2","first-page":"825","article-title":"Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis","volume":"188","author":"Eyre DR","year":"1980","journal-title":"Bio\u2010chem J"},{"key":"e_1_2_1_9_2","first-page":"788","article-title":"Metabolic response during early stages of surgically\u2010induced osteoarthritis in mature beagles","volume":"7","author":"Schwartz ER","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260110"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(78)90180-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_1_13_2","first-page":"13","volume-title":"Preparation of acid and citrate soluble collagen, Methodology of Connective Tissue Research","author":"Bazin S","year":"1976"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1964.tb14213.x"},{"key":"e_1_2_1_15_2","first-page":"1459","article-title":"Ultrastructural characteristics of osteoarthritis","volume":"32","author":"Weiss C","year":"1973","journal-title":"Fed Proc"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2106\/00004623-197254050-00002","article-title":"An ultrastructural study of osteoarthritic changes in the articular cartilage of human knees","volume":"54","author":"Weiss C","year":"1972","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(81)90040-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210704"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108632"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197705052961801"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(81)90050-0"}],"container-title":["Arthritis &amp; 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