{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:27:28Z","timestamp":1790940448580,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8186,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A partial lateral meniscectomy procedure has been developed for the induction of a predictable and reproducible degenerative joint disease in knees of rabbits. The procedure adopted involves section of the fibular collateral and sesamoid ligaments and removal of 4\u20105 mm of the anterior lateral meniscus. In most experiments the animals are killed and tissues obtained for histologic examination at 6 weeks. Section of the ligaments alone (with or without penetration of the joint space) did not result in significant pathologic change. Significant degeneration was observed in tibial and femoral cartilage when the meniscus as well as the ligaments were cut, but the most extensive lesions were seen when a piece of the anterolateral meniscus was actually removed. These lesions included fibrillation, ulceration and erosion, \u201cclone\u201d and osteophyte formation, loss of chondrocytes, and loss of safraninophilic staining in the articular cartilage. The incidence and distribution of lesions with time following surgery were also investigated. Lesions were observed as early as 1\u20102 weeks post\u2010surgery and increased in number and severity up to 12 weeks. A global scoring system has been devised to permit statistical comparisons of lesion incidence and severity in different groups of rabbits. This scoring system has enabled us to test drug efficacy in the rabbit lateral meniscectomy model of osteoarthritis.<\/jats:p>","DOI":"10.1002\/art.1780260709","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:12:52Z","timestamp":1171483972000},"page":"875-886","source":"Crossref","is-referenced-by-count":95,"title":["A new model of osteoarthritis in rabbits"],"prefix":"10.1002","volume":"26","author":[{"given":"C.","family":"Colombo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Swartzendruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Selwyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Steinetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000136607"},{"key":"e_1_2_1_3_2","first-page":"1178","article-title":"Canine hip dysplasia","volume":"8","author":"Schnelle G","year":"1959","journal-title":"Lab Invest"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.19.4.369"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160317"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197207000-00033"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00003086-198003000-00053","article-title":"Induction of osteoarthritis in the rabbit knee joint: histological changes following meniscectomy and meniscal lesions","volume":"147","author":"Shapiro F","year":"1980","journal-title":"Clin Orthop"},{"key":"e_1_2_1_8_2","first-page":"683","article-title":"Experimentally induced osteoarthritis in guinea pigs: effect of surgical procedure and dietary intake of vitamin C","volume":"31","author":"Schwartz ER","year":"1981","journal-title":"Lab Anim Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.1.12"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2106\/00004623-197860060-00009","article-title":"Effects of medial meniscectomy in patients older than forty years","volume":"60","author":"Jones RE","year":"1978","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_11_2","first-page":"38","volume-title":"Manual of Histological Staining Methods of the Armed Forces Institute of Pathology","author":"Luna LG","year":"1968"},{"key":"e_1_2_1_12_2","first-page":"507","volume-title":"Istopathological Technic and Practical Histochemistry","author":"Lillie RD","year":"1965"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2106\/00004623-197355050-00017","article-title":"Acid hydrolase activity in osteoarthritic and normal human cartilage","volume":"55","author":"Ehrlich MG","year":"1973","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1139\/o66-093"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001968"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220108"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1800403"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02024175"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541217"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003086-198105000-00033","article-title":"Catabolin\u2014a cartilage catabolic factor from synovium","volume":"156","author":"Dingle JT","year":"1981","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1990705"},{"key":"e_1_2_1_22_2","first-page":"18","article-title":"The role of the meniscus in an instability model of osteoarthritis in the rabbit knee","volume":"63","author":"Minns RJ","year":"1982","journal-title":"Br J Exp Pathol"}],"container-title":["Arthritis &amp; 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