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Schirmer tests documented dry eyes in NZB\/NZW and PN mice; other autoimmune strains and controls had normal tear formation. All autoimmune mice had conjunctivitis, but this abnormality was most severe in the PN strain. Ninety\u2010eight percent of MRL\/1 and MRL\/n mice had mononuclear cell infiltrates in lacrimal glands, and salivary glands were involved to a lesser degree. New Zealand mice and PN mice had smaller gland lesions. The extensive gland destruction in MRL\/l and MRL\/n mice suggested that these substrains merit further studies as animal models of Sj\u00f6gren's syndrome.<\/jats:p>","DOI":"10.1002\/art.1780270206","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:52:58Z","timestamp":1171486378000},"page":"157-165","source":"Crossref","is-referenced-by-count":114,"title":["Sj\u00f6gren's syndrome in MRL\/l and MRL\/n mice"],"prefix":"10.1002","volume":"27","author":[{"given":"Robert W.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Alspaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim S.","family":"Waggie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Ellen","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_1_3_2","first-page":"971","volume-title":"Sj\u00f6gren's syndrome, Textbook of Rheumatology","author":"Alspaugh MA","year":"1981"},{"key":"e_1_2_1_4_2","first-page":"12","volume-title":"Sj\u00f6gren's Syndrome","author":"Shearn MA","year":"1971"},{"key":"e_1_2_1_5_2","first-page":"199","article-title":"The spectrum of benign to malignant lymphoproliferation in Sj\u00f6gren's syndrome","volume":"9","author":"Anderson LG","year":"1971","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700880227"},{"key":"e_1_2_1_7_2","first-page":"681","article-title":"Experimental induction of immune sialadenitis in guinea\u2010pigs using different adjuvants","volume":"17","author":"Whaley K","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_8_2","first-page":"671","article-title":"A laboratory model of Sj\u00f6gren's syndrome","volume":"52","author":"Kessler HS","year":"1968","journal-title":"Am J Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60444-7"},{"key":"e_1_2_1_10_2","first-page":"143","volume-title":"Lymphoproliferation (lpr) and other single\u2010locus models for murine lupus, Immunologic Defects in Laboratory Animals","author":"Murphy ED","year":"1981"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.6.1690"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.5.1671"},{"key":"e_1_2_1_13_2","first-page":"932","article-title":"Palmerston North mice: a new animal model of systemic lupus erythematosus","volume":"92","author":"Walker SE","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260511"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.21.5.656"},{"key":"e_1_2_1_16_2","first-page":"8","volume-title":"Further observations on a phosphate buffer for osmium solutions in fixation, Proceedings of the Fifth International Congress of Electron Microscopy","author":"Millonig G","year":"1962"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(81)82558-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108007"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230304"},{"key":"e_1_2_1_20_2","first-page":"102","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967"},{"key":"e_1_2_1_21_2","first-page":"1","article-title":"Zur Kenntnis der Keratoconjunctivitis Sicca (Keratitis fila\u2010formis bei Hypofunktion der Tranendrusen)","volume":"11","author":"Sj\u00f6gren H","year":"1933","journal-title":"Acta Ophthalmol (suppl 2)"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1971.00990050213016"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1977.tb01651.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809111939"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455876"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jnci\/59.1.199","article-title":"Immunopathogenicity and oncogenicity of murine leukemia virus. 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