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The HLA\u2010B27 negative relatives did not have features of either disease. In the population study of 2,957 individuals 45 years or older, we found 5 cases of HLA\u2010B27 positive sacroiliitis (according to the New York criteria) and 3 of these fulfilled the New York criteria for diagnosis of AS. In 2 of these 3 individuals, the diagnosis was made on clinical grounds. The pheno\u2010type frequency of HLA\u2010B27 in this population is 7.8%, or about 230 HLA\u2010B27 positive individuals in this population sample. Since AS was found in only 3 individuals, 1.3% of the HLA\u2010B27 positive individuals in the population at large have AS; therefore, our data show that among individuals 45 years or older, 21% of HLA\u2010B27 positive relatives of HLA\u2010B27 positive AS patients have AS as compared with 1.3% of the HLA\u2010B27 positive individuals in the population at large. Thus, the risk for AS is 16 times greater in the HLA\u2010B27 positive relatives compared with HLA\u2010B27 positive individuals in the population at large. The discriminatory value of the New York criterion of history of pain or the presence of pain at the dorsolumbar junction or in the lumbar spine was analyzed in the population and family studies and was found to be too nonspecific.<\/jats:p>","DOI":"10.1002\/art.1780270301","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T15:51:59Z","timestamp":1171468319000},"page":"241-249","source":"Crossref","is-referenced-by-count":403,"title":["The risk of developing ankylosing spondylitis in HLA\u2010B27 positive individuals"],"prefix":"10.1002","volume":"27","author":[{"given":"Sjef M. Der","family":"Van Linden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Valkenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartelt M. 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