{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:32Z","timestamp":1760188832721},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the in vitro T lymphocyte tritiated thymidine (<jats:sup>3<\/jats:sup>HTdr) incorporation response of Reiter's patients in the United States to a serotype 3 strain of <jats:italic>Yersinia enterocolitica<\/jats:italic>. The mean <jats:sup>3<\/jats:sup>HTdr incorporation response to the formalin killed form of this strain was 27,409 \u00b1 5,488 counts per minute for 14 HLA\u2010B27 positive Reiter's patients compared with 5,414 \u00b1 3,490 cpm for a control group of 11 HLA\u2010B27 positive normal individuals (<jats:italic>P<\/jats:italic> &lt; 0.0005). This high response in Reiter's patients was observed with the formalin killed form of <jats:italic>Y enterocolitica<\/jats:italic> serotype 3, but not with a heat killed form or a rough mutant form derived from the same bacterial strain. Further, <jats:italic>Y enterocolitica<\/jats:italic> of a different serotype (serotype 8) which is not associated with reactive arthritis failed to induce the high proliferative response observed with the serotype 3 strain. This response indicates that T lymphocytes from spontaneous Reiter's patients are capable of recognizing and proliferating to determinant(s) on the formalin killed form of <jats:italic>Y enterocolitica<\/jats:italic> serotype 3. Since this bacterium is associated with Reiter's syndrome in Europe but not the United States, these data are consistent with the possibility that our patients have previously encountered these or similar determinants through unrecognized infection with other microorganisms.<\/jats:p>","DOI":"10.1002\/art.1780270302","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:51:59Z","timestamp":1171486319000},"page":"250-257","source":"Crossref","is-referenced-by-count":22,"title":["In vitro t lymphocyte proliferative response to <i>yersinia enterocolitica<\/i> in reiter's syndrome"],"prefix":"10.1002","volume":"27","author":[{"given":"Michael B.","family":"Brenner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig W.","family":"Wiesenhutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur K.","family":"Huberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T. Y.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1964.tb00634.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.198.7.693"},{"key":"e_1_2_1_4_2","first-page":"30","article-title":"Human yersiniosis in Finland. I. Bacteriology and serology","volume":"4","author":"Ahvonen P","year":"1972","journal-title":"Ann Clin Res"},{"key":"e_1_2_1_5_2","first-page":"39","article-title":"Human yersiniosis in Finland. II. Clinical features","volume":"4","author":"Ahvonen P","year":"1972","journal-title":"Ann Clin Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.31.1.34"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170505"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200512"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250302"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-1-94"},{"key":"e_1_2_1_11_2","first-page":"27","article-title":"Reiter's disease and HL\u2010A27","volume":"34","author":"Nicholls A","year":"1975","journal-title":"Ann Rheum Dis (suppl)"},{"key":"e_1_2_1_12_2","first-page":"588","article-title":"Reiter's syndrome","volume":"20","author":"Ford DK","year":"1970","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_13_2","first-page":"291","article-title":"Diagnostic criteria for population studies","volume":"13","author":"Kellgren JH","year":"1962","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/69.2.103"},{"key":"e_1_2_1_15_2","first-page":"149","volume-title":"Methods in Immunology","author":"Garvey JS","year":"1972"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196601981"},{"key":"e_1_2_1_17_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulo\u2010cytes from human blood","volume":"21","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest (suppl 97)"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(76)90050-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4049\/jimmunol.119.1.156","article-title":"Human monocyte\u2010lymphocyte interaction: a new technique","volume":"119","author":"Fan PT","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","first-page":"474","volume-title":"Immune response to Yersinia and Pasteurella, Manual of Clinical Immunology","author":"Winblad S","year":"1980"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408417709102312"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197903373"},{"key":"e_1_2_1_23_2","first-page":"220","article-title":"Cell\u2010mediated immune responses of synovial mononuclear cells to sexually transmitted, enteric and mumps antigens in patients with Reiter's syndrome, rheumatoid arthritis and ankylosing spondylitis","volume":"8","author":"Ford DK","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541172"},{"key":"e_1_2_1_25_2","first-page":"46","article-title":"Aberrant immunity in (HL\u2010A)W27\u2010positive rheumatic disease","volume":"34","author":"Bluestone R","year":"1975","journal-title":"Ann Rheum Dis (suppl)"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1978.tb00403.x"},{"key":"e_1_2_1_27_2","first-page":"969","article-title":"Reiter's syndrome following epidemic Shigellosis","volume":"8","author":"Simon DG","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90542-3"},{"key":"e_1_2_1_29_2","first-page":"83","article-title":"Biotypic and serotypic profiles of 367 Yersinia enterocolitica cultures of human and environmental origin in the United States","volume":"5","author":"Quan TJ","year":"1979","journal-title":"Contrib Microbiol Immunol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1128\/jcm.4.2.137-144.1976","article-title":"Yersinia enterocolitica isolates from humans in California","volume":"4","author":"Bissett ML","year":"1976","journal-title":"J Clin Microbiol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780270302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:49:40Z","timestamp":1700718580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780270302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1002\/art.1780270302"],"URL":"https:\/\/doi.org\/10.1002\/art.1780270302","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}