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Calcium uptake by sarcoplasmic reticulum vesicles from patients with polymyositis was 50% less than that by vesicles from controls (<jats:italic>P<\/jats:italic> &lt; 0.001). In contrast, no difference in calcium\u2010dependent ATPase activity was noted between vesicles from patients with polymyositis and controls. The demonstrated defect may be important in the pathogenesis of muscle weakness in polymyositis.<\/jats:p>","DOI":"10.1002\/art.1780270309","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T15:51:59Z","timestamp":1171468319000},"page":"299-304","source":"Crossref","is-referenced-by-count":5,"title":["Dysfunction of the sarcoplasmic reticulum in polymyositis"],"prefix":"10.1002","volume":"27","author":[{"given":"Apostolos E.","family":"Kalovidouris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"742","volume-title":"Polymyositis and dermatomyositis, Arthritis and Allied Conditions","author":"Pearson CM","year":"1979"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_1_4_2","first-page":"83","volume-title":"Biochemical and clinical aspects of sarcoplasmic reticulum function, Current Topics in Membranes and Transport","author":"Martonosi A","year":"1972"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.01.060172.001203"},{"key":"e_1_2_1_6_2","first-page":"329","article-title":"Study of the kinetics of calcium transport by isolated fragmented sarcoplasmic reticulum","volume":"345","author":"Weber A","year":"1966","journal-title":"Biochem Z"},{"volume-title":"Aid to the Investigation of Peripheral Nerve Injuries","year":"1943","author":"British Medical Research Council","key":"e_1_2_1_7_2"},{"key":"e_1_2_1_8_2","first-page":"64","article-title":"Electrical activity of muscle in polymyositis","volume":"79","author":"Lambert EH","year":"1954","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_9_2","first-page":"240","article-title":"Inclusion body myositis","volume":"25","author":"Yunis EJ","year":"1971","journal-title":"Lab Invest"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.1.8"},{"key":"e_1_2_1_11_2","first-page":"144","article-title":"Mitogen\u2010activated human mononuclear cells suppress calcium binding by sarcoplasmic reticulum","volume":"95","author":"Kalovidouris AE","year":"1980","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_1_14_2","first-page":"648","article-title":"Sarcoplasmic reticulum. 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