{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T14:23:29Z","timestamp":1726064609803},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7911,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rate of aspirin (acetyIsalicylic acid, ASA) deacetylation to salicylate in vivo determines the availability of the intact molecule for therapeutically important transacetylation reactions. Experiments were carried out to assess the relative contribution of a previously isolated human erythrocyte ASA esterase to the overall hydrolysis rate in vivo, as opposed to similar enzymes in other tissues. In vitro, the rates of ASA hydrolysis were relatively slow in plasma from humans and dogs. The hydrolysis rates were significantly greater in whole blood in dogs, rabbits, and humans. In human and canine whole blood, the rate of hydrolysis correlated positively with hematocrit. In vivo studies with dogs showed that ASA decay rates conform to a 2\u2010compartment model. After reduction of hematocrit by a mean of 49% in 4 dogs without previous splenectomy, the \u201cavailability\u201d of ASA increased. In 4 dogs with previous splenectomy, this measurement was increased even more after comparable hematocrit reduction. In 2 dogs that underwent a sub\u2010total hepatectomy, ASA availability increased by only 35% and 12.8%, respectively. These results suggest a significant role for the erythrocyte esterase in vivo in the dog and possibly in humans.<\/jats:p>","DOI":"10.1002\/art.1780270409","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:49:03Z","timestamp":1171486143000},"page":"422-426","source":"Crossref","is-referenced-by-count":17,"title":["The Relative Roles of Hydrolases of the Erythrocyte and Other Tissues in Controlling Aspirin Survival in Vivo"],"prefix":"10.1002","volume":"27","author":[{"given":"Patrick B.","family":"Costello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Caruana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floyd A.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005223022105"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108941"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.8.3073"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250509"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260414"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600670540"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600570807"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600610312"},{"key":"e_1_2_1_10_2","first-page":"726","article-title":"Insulin, glucagon and glucose in the regeneration response of the liver","volume":"153","author":"Caruana JA","year":"1981","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_11_2","first-page":"213","volume-title":"Basic Biostatistics in Medicine and Epidemiology","author":"Rimm AA","year":"1980"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106011"},{"key":"e_1_2_1_13_2","unstructured":"DeFuriaFG BridgesKF BunnHF LeeYS PetersonCM SchmidtG JensenM CeramiA:The acetylation of hemoglobin by aspirin First International Symposium on Sickle Cell Disease 1974 pp185\u2013186"},{"key":"e_1_2_1_14_2","first-page":"55","article-title":"Acetylation of erythrocyte membrane peptides by aspirin","volume":"20","author":"Green FA","year":"1980","journal-title":"Transfusion"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.29.17"},{"key":"e_1_2_1_16_2","volume-title":"Juvenile rheumatoid arthritis, model no. 92, Handbook: Animal Models of Human Disease","author":"Allen HL","year":"1977"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(78)80005-5"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780270409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:40:46Z","timestamp":1700718046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780270409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1002\/art.1780270409"],"URL":"https:\/\/doi.org\/10.1002\/art.1780270409","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}