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The exposure of rats to native type II collagen at day 7 or 10 after immunization suppressed the incidence of arthritis and anticollagen antibody levels, although the cellular response was not affected. The exposure to denatured type II collagen offered partial protection, while type I collagen had no significant effect. Rats immunized with <jats:italic>Mycobacterium tuberculosis<\/jats:italic> also showed reduced arthritic response when subsequently treated with type II collagen. The common modalities between the 2 models and the possible role of type II collagen in the interference with the inflammatory arthritic events are discussed.<\/jats:p>","DOI":"10.1002\/art.1780270711","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:45:09Z","timestamp":1171485909000},"page":"797-806","source":"Crossref","is-referenced-by-count":17,"title":["Collagen\u2010induced and adjuvant\u2010induced arthritis in rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Kalindi","family":"Phadke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Fouts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"135","article-title":"Immunogenicity and specificity of collagen. 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