{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:06Z","timestamp":1790745846839,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7820,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>University of California, Davis (UCD) line 200 chickens develop an inherited connective tissue disease which includes fibrosis, vascular occlusion, and lymphocytic infiltration of skin, comb, and viscera. To further identify the nature of these features, tissue from both affected and control chickens, aged 7 days to 12 months, was serially examined using hematoxylin\u2010eosin and Masson's trichrome stain. Mononuclear cell accumulations in skin were simultaneously characterized using mouse anti\u2010chicken T and B cell specific monoclonal antibodies in a solid\u2010phase immunoperoxidase assay; the same cells were also examined by direct immunofluorescence with fluoresceinated anti\u2010chicken IgM and IgG, and stained for esterase and acid phosphatase. At 6 weeks of age, the majority of line 200 chicks manifested dermal fibrosis, cellular infiltrates, and vessel anomalies. In contrast, visceral involvement did not reach maximum incidence until 5 months of age with involvement of small intestine (60%), lungs (60%), and kidneys (65%), and not until 1 year for esophagus (64%), heart (30%), and testes (66%). Moreover, and of particular interest, was the threefold increment of full\u2010thickness skin biopsies in line 200 birds. The cellular infiltrates in skin, found in 100% of affected line 200 chickens, were positive for B1, a mature B cell marker found on peripheral blood and bursal B cells; the majority of these same cells were found to bear surface IgM but not IgG. These data suggest that this syndrome may result from an alteration in collagen metabolism associated with a mature subpopulation of B lymphocytes.<\/jats:p>","DOI":"10.1002\/art.1780270712","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:45:09Z","timestamp":1171485909000},"page":"807-815","source":"Crossref","is-referenced-by-count":34,"title":["Serial observations and definition of mononuclear cell infiltrates in avian scleroderma, an inherited fibrotic disease of chickens"],"prefix":"10.1002","volume":"27","author":[{"given":"Judy Van De","family":"Water","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Abplanalp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Von Der","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.6.1640"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780030607"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-2-317"},{"key":"e_1_2_1_5_2","first-page":"98","article-title":"The skin as a reflector of immunologic change: oculocutaneous manifestations of rheumatic diseases","volume":"4","author":"Sams WM","year":"1973","journal-title":"Rheumatology"},{"key":"e_1_2_1_6_2","first-page":"319","article-title":"Syngeneic inbred lines of chicken and their use in immunogenetics","volume":"88","author":"Morrow PR","year":"1977","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_1_7_2","volume-title":"Histopathologic Technique and Practical Histochemistry","author":"Lillie RD","year":"1965"},{"key":"e_1_2_1_8_2","first-page":"378","volume-title":"Hybridomas: a new dimension in biological analyses, Monoclonal Antibodies","author":"Jonak ZL","year":"1980"},{"key":"e_1_2_1_9_2","unstructured":"FlotteTJ SpringerTA ThorbeckeGJ:Dendritic cell and macrophage staining by monoclonal antibodies(in press)"},{"key":"e_1_2_1_10_2","first-page":"244","volume-title":"Histochemistry","author":"Barka T","year":"1963"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.79.2.342"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04474.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(81)80010-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90300-0"},{"key":"e_1_2_1_15_2","first-page":"525","article-title":"Synthesis of fibronectin, laminin, and several collagens by a liver\u2010derived epithelial line","volume":"42","author":"Foidart JM","year":"1980","journal-title":"Lab Invest"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4049\/jimmunol.106.2.371","article-title":"Development and distribution of immunoglobulin\u2010containing cells in the chicken","volume":"106","author":"Kincade PW","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(74)90015-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90201-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2340\/0001555561371380","article-title":"In situ identification of mononuclear cells in cutaneous infiltrates in discoid lupus erythematosus, sarcoidosis and secondary syphillis","volume":"61","author":"Bjerke JR","year":"1981","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.6.1326"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108594"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.3.483"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-59-3-351"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(82)90055-5"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-2-150"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.54.6.490"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780270712","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:11:00Z","timestamp":1700727060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780270712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1984,7]]}},"alternative-id":["10.1002\/art.1780270712"],"URL":"https:\/\/doi.org\/10.1002\/art.1780270712","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}