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Rheumatoid synovial membranes contained a mean of 48.5 mast cells per 20 high\u2010power fields (HPF) (range 0\u2013252), and control synovial membranes had a mean of 3.9 mast cells per 20 HPF (range 0\u201313) (<jats:italic>P<\/jats:italic> &lt; 0.001). In a comparison of high and low mast cell subgroups in rheumatoid arthritis, counts were directly related to the intensity of clinical synovitis in the affected joint, but not to hemoglobin concentration or erythrocyte sedimentation rate. Joints excised from 5 patients with rheumatoid arthritis were characterized by active bone remodeling with increased osteoid, active resorption by osteoclasts, and trabecular osteoporosis. Mast cells were prominent in both extraosseous pannus and intraosseous invasive tissue. The possible roles of mast cells in the pathogenesis of rheumatoid arthritis are discussed.<\/jats:p>","DOI":"10.1002\/art.1780270802","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:40:50Z","timestamp":1171485650000},"page":"845-851","source":"Crossref","is-referenced-by-count":156,"title":["Articular mastocytosis in rheumatoid arthritis"],"prefix":"10.1002","volume":"27","author":[{"given":"Adrian J.","family":"Crisp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford M.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Krane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780030205"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196446040-00026"},{"key":"e_1_2_1_4_2","first-page":"489","article-title":"Ultrastructure of the synovial membrane","volume":"5","author":"Schumacher HR","year":"1975","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.1.24"},{"key":"e_1_2_1_6_2","first-page":"43","article-title":"Elektronen mikroskopische Untersuchung des Synovial gewebes bei der juvenilen rheumatoiden Arthritis","volume":"33","author":"Bierther M","year":"1974","journal-title":"Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(78)90027-6"},{"key":"e_1_2_1_8_2","first-page":"127","volume-title":"Role of basophils and mast cells in juvenile rheumatoid arthritis, The Mast Cell: Its Role in Health and Disease","author":"Athreya BH","year":"1979"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.6.515"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197805000-00004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80141-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820301)49:5<927::AID-CNCR2820490517>3.0.CO;2-B"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/300188a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4049\/jimmunol.127.2.794","article-title":"Long term in vitro culture of murine mast cells. 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Purification of a mast cell growth factor and its dissociation from TCGF","volume":"127","author":"Yung Y\u2010P","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110418"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910180520"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(82)90291-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.4.931"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(78)90271-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb53695.x"},{"key":"e_1_2_1_21_2","first-page":"105","article-title":"Biosynthesis and release of prostaglandins by mast cells","volume":"59","author":"Tolone G","year":"1978","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4049\/jimmunol.123.4.1663","article-title":"Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells","volume":"123","author":"Lewis RA","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/293103a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108917"},{"key":"e_1_2_1_25_2","first-page":"103","volume-title":"Acid hydrolases and other enzymes of rat and human mast cell secretary granules, Biochemistry of the Acute Allergic Reactions","author":"Schwartz LB","year":"1981"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195907232610406"},{"key":"e_1_2_1_27_2","first-page":"239","article-title":"Accumulation of mast cells in endosteum of bones of calcium\u2010deficient rats","volume":"63","author":"Urist MR","year":"1957","journal-title":"Arch Pathol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02061971"},{"key":"e_1_2_1_29_2","first-page":"17","article-title":"Mast cells in areas of experimental bone resorption and remodelling","volume":"50","author":"Severson AR","year":"1969","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02017533"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90567-1"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196809192791203"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405002"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80084-6"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.12.947"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.147.3656.407"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-87-6-1211"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/22.1.22"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0946-8_33"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.130.4.1891"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1870521"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.130.1.341"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780270802","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:34:22Z","timestamp":1692970462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780270802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1984,8]]}},"alternative-id":["10.1002\/art.1780270802"],"URL":"https:\/\/doi.org\/10.1002\/art.1780270802","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8]]}}}