{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:52:35Z","timestamp":1761540755986},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7758,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Von Willebrand factor (vWF) antigen levels were measured in 39 patients with biopsy\u2010proven giant cell arteritis (GCA), 16 patients with polymyalgia rheumatica (PMR), 12 patients with Sj\u00f6gren's syndrome, and 7 with choroiditis, as well as in 20 age\u2010 and sex\u2010matched controls. Among GCA patients, 31 (group A) had clinically inactive disease and were taking low\u2010dose glucocorticoids for at least 1 year; their vWF levels were high even in the presence of a normalized erythrocyte sedimentation rate (ESR). When the ESR and vWF were analyzed in another 8 GCA patients (group B) before and after treatment with glucocorticoids, vWF remained elevated even though the ESR returned to normal. Among the highest levels of vWF were those of 3 GCA patients who presented with ocular symptoms and positive temporal artery biopsies, but normal ESR. The presence of elevated vWF was not specific for GCA since elevated levels were also found in patients with PMR, Sj\u00f6gren's syndrome, and choroiditis. The levels of vWF in GCA were significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.01) than in these other conditions associated with myalgias and eye symptoms. Elevation of vWF levels may help in the differential diagnosis of GCA, particularly when the ESR is normal and ocular symptoms are present.<\/jats:p>","DOI":"10.1002\/art.1780270912","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:40:49Z","timestamp":1171485649000},"page":"1046-1049","source":"Crossref","is-referenced-by-count":51,"title":["Elevation of von willebrand factor is independent of erythrocyte sedimentation rate and persists after glucocorticoid treatment in giant cell arteritis"],"prefix":"10.1002","volume":"27","author":[{"given":"Augusto B.","family":"Federici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert I.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis R.","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore S.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"980","article-title":"Giant cell arteritis: a review","volume":"29","author":"Hunder G","year":"1978","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_3_2","first-page":"504","article-title":"Skip lesions in temporal arteritis","volume":"51","author":"Klein R","year":"1976","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_4_2","first-page":"57","article-title":"Light and electron microscopic studies on human temporal arteries with special reference to alterations related to senescence, atherosclerosis, and giant cell arteritis","volume":"79","author":"Parker F","year":"1975","journal-title":"Am J Pathol"},{"key":"e_1_2_1_5_2","first-page":"1189","volume-title":"Giant cell arteritis and polymyalgia rheumatica, Textbook of Rheumatology","author":"Hunder G","year":"1981"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230909"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.4.360"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107471"},{"key":"e_1_2_1_9_2","first-page":"849","article-title":"Polymyalgia rheumatica","volume":"44","author":"Hunder GG","year":"1969","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_10_2","first-page":"339","volume-title":"Factor VIII related antigen, Immunoassays: Clinical Laboratory Techniques for the 1980s","author":"Zimmerman TS","year":"1980"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.2.168"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-4-482"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-3-337"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(79)90169-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91068-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409122911101"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780270912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780270912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:46:12Z","timestamp":1700725572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780270912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1002\/art.1780270912"],"URL":"https:\/\/doi.org\/10.1002\/art.1780270912","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}