{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:31:54Z","timestamp":1791322314943,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationships of HLA\u2014DR and the newer DS (second D locus) B cell alloantigens (MB and MT) to the clinical and serologic expression of primary and secondary forms of Sj\u00f6gren's syndrome (SS) were examined in 102 patients (86 whites and 16 blacks). Although HLA\u2010DR3 was significantly increased in whites (25 of 50, 50%) and blacks (4 of 5, 80%) with primary SS compared with race\u2010matched normal controls, it was not appreciably elevated in those with systemic lupus erythematosus (SLE)\u2010SS, rheumatoid arthritis (RA)\u2010SS, or connective tissue disease\u2010SS. The MT2 specificity, however, was more strongly associated with primary SS (86% of whites and 100% of blacks) and also with SLE\u2010SS and RA\u2010SS compared with race\u2010matched normal controls. Furthermore, MT2 was significantly increased in SLE\u2010SS and RA\u2010SS when compared with non\u2010sicca SLE and RA controls. Although primary and secondary SS were most strongly associated with this DS specificity (MT2), the anti\u2010Ro (SS\u2010A) and anti\u2010La (SS\u2010B) antibody responses were more closely allied to DR antigens. HLA\u2010DR3 was increased in anti\u2010Ro positive patients, both whites and blacks, with primary SS (74%) and in total anti\u2010Ro positive subjects (54%) compared with their anti\u2010Ro negative counterparts (38% and 31%, respectively). Among DR3 negative patients, HLA\u2010DR2 correlated with anti\u2010Ro in both primary SS (83%) and in the total SS group (58%). Thus, 96% of Ro antibody positive patients with primary SS had DR3 and\/or DR2, as did 80% of anti\u2010Ro positive subjects in all categories. Antibodies to La (SS\u2010B) correlated only with DR3 in primary SS and in the total group. These data suggest that MT2 is the strongest major histocompatibility complex determinant for primary and secondary SS. However, HLA\u2010DR3 and DR2 may mediate the Ro\/La antibody responses that are characteristic of more severe disease. The clinical expression of Sj\u00f6gren's syndrome appears to result from the complex genetic interplay of multiple HLA\u2010D region factors.<\/jats:p>","DOI":"10.1002\/art.1780271106","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:09:56Z","timestamp":1171483796000},"page":"1245-1253","source":"Crossref","is-referenced-by-count":104,"title":["Sj\u00f6ugren's syndrome influence of multiple hla\u2010d region alloantigens on clinical and serologic expression"],"prefix":"10.1002","volume":"27","author":[{"given":"Raymond W.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Provost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma B.","family":"Bias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine L.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Edlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc C.","family":"Hochberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Betty","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1046","article-title":"Advances in the diagnosis and concept of Sj\u00f6gren's syndrome (autoimmune exocrinopathy)","volume":"30","author":"Strand V","journal-title":"Bull Rheum 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