{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:44:53Z","timestamp":1779126293882,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new antigen (Su) from calf thymus nuclear extract that reacts with sera from patients with systemic lupus erythematosus (SLE) is described. Antibodies to Su, demonstrated by immunodiffusion, were most frequently found in patients with a diagnosis of probable or definite SLE. Thirty\u2010seven percent of patients with Su antibodies and a diagnosis of SLE were positive for antinuclear antibodies by indirect immunofluorescence, but lacked specific antibodies previously associated with SLE. Patients with Su antibodies exhibited a higher frequency of Raynaud's phenomenon, but exhibited a lower frequency of malar rash, alopecia, and arthritis when compared with SLE patients in previously published reports. The Su antigen is weakly acidic, heatstable at 37\u00b0C, heat\u2010sensitive at 56\u00b0C, resistant to DNase and RNase, but sensitive to trypsin. Its molecular weight approximated 154,000 daltons by Sepharose chromatography. The Su antibody may be associated with a subset of SLE patients with distinct clinical features, and may serve as a serologic marker for patients who are positive for fluorescent antinuclear antibodies but have no other detectable SLE\u2010associated antibodies.<\/jats:p>","DOI":"10.1002\/art.1780271108","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:09:56Z","timestamp":1171483796000},"page":"1263-1271","source":"Crossref","is-referenced-by-count":23,"title":["Characterization of a new antigen\u2010antibody system (su) in patients with systemic lupus erythematosus"],"prefix":"10.1002","volume":"27","author":[{"given":"Edward L.","family":"Treadwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Alspaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-4-464"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.96.3.464"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108007"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230304"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108637"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220719"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109529"},{"key":"e_1_2_1_10_2","first-page":"S94","article-title":"Distinction of PM\u20101 from three new antigens associated with rheumatic diseases (abstract)","volume":"24","author":"Treadwell EL","year":"1981","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_12_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus eythematosus","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_13_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(72)90013-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109809"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_17_2","first-page":"76","article-title":"Antibodies to Mi\u20101 in SLE: relationship to other precipitins and reaction with bovine immunoglobulin","volume":"53","author":"Targoff IN","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_18_2","first-page":"602","volume-title":"Immunopathology","author":"Nakamura RM","year":"1974"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106502"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200308"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197611182952101"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108616"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86738-8"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.4049\/jimmunol.107.5.1281","article-title":"Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera","volume":"107","author":"Mattioli M","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110295"},{"key":"e_1_2_1_27_2","first-page":"328","volume-title":"Methods in Immunology","author":"Garvey JS","year":"1979"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230802"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250710"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198103000-00002"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(75)40011-8"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.2307\/2983604"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070150014003"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.2.171"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5871.88"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170212"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150510"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780271108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780271108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:46:24Z","timestamp":1700754384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780271108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1002\/art.1780271108"],"URL":"https:\/\/doi.org\/10.1002\/art.1780271108","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}