{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:59:09Z","timestamp":1760266749707},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA\u2010DR, C4, and Bf typing was performed in 99 patients with juvenile rheumatoid arthritis (JRA). DR1 was found with higher frequency in patients with polyarticular JRA than in controls (<jats:italic>P<\/jats:italic> &lt; 0.05). DR3 was more common in patients with fever and\/or rash than in those without these manifestations (<jats:italic>P<\/jats:italic> &lt; 0.05). A significant negative association between JRA and C4A6 (<jats:italic>P<\/jats:italic> &lt; 0.05), C4BQ0 (<jats:italic>P<\/jats:italic> &lt; 0.0005), and BfF1 (<jats:italic>P<\/jats:italic> &lt; 0.05) was found. It is possible that a disequilibrium between DR and C4\/Bf genes plays a role in the pathogenesis of JRA.<\/jats:p>","DOI":"10.1002\/art.1780271110","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:09:56Z","timestamp":1171483796000},"page":"1281-1285","source":"Crossref","is-referenced-by-count":20,"title":["Dr, C4, and BF allotypes in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"27","author":[{"given":"A.","family":"Arnaiz\u2010Villena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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