{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:43:21Z","timestamp":1787165001120,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7636,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1985,1]]},"abstract":"Abstract<\/jats:title>\n \n We report 2 independently\u2010conducted family studies of HLA\u2010B27 positive probands with ankylosing spondylitis (AS), both of which support the view that the clinical spectrum of AS is broader than ordinarily assumed, and should include individuals who have symptomatic disease but who do not show radiologic evidence of abnormalities of the sacroiliac joints or the spine. In the Cleveland study of 100 relatives of 30 B27 positive AS probands, 9 relatives did not show radiologic abnormalities of the sacroiliac joints or the spine but had symptoms of chronic inflammatory back pain previously reported to be characteristic of AS. These 9 relatives were all subsequently found to possess B27, in contrast with only 27 of 60 asymptomatic relatives (\n P<\/jats:italic>\n < 0.01). In the Leiden study of 101 relatives of 20 randomly chosen B27 positive AS probands, 13 of 86 relatives without radiographic evidence of sacroiliitis reported \u201cthoracic pain and stiffness,\u201d as defined in the Rome criteria for AS. Twelve of these 13 symptomatic relatives were B27 positive. In contrast, among the remaining 73 relatives, only 33 were B27 positive (\n P<\/jats:italic>\n < 0.01). The occurrence of these characteristic spondylitic symptoms in B27 positive, but not B27 negative, relatives of AS probands suggests that the spectrum of the clinical manifestations of AS may include individuals with symptomatic disease, but without radiographic evidence of abnormalities of the sacroiliac joints or the spine. The relatively large number of females we found in this group suggests that women are more likely to manifest this variety of disease than are men.\n <\/jats:p>","DOI":"10.1002\/art.1780280107","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T15:40:27Z","timestamp":1171467627000},"page":"40-43","source":"Crossref","is-referenced-by-count":125,"title":["Spondylitic disease without radiologic evidence of sacroiliitis in relatives of HLA\u2010B27 positive ankylosing spondylitis patients"],"prefix":"10.1002","volume":"28","author":[{"given":"Muhammad A.","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjef M.","family":"van Der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Valkenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Cats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"291","article-title":"Diagnostic criteria for population studies","volume":"13","author":"Kellgren JH","year":"1962","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_3_2","first-page":"456","volume-title":"Population Studies of the Rheumatic Diseases","author":"Bennett PH","year":"1968"},{"key":"e_1_2_1_4_2","first-page":"301","article-title":"Genetics of HLA associated disease: ankylosing spondylitis","volume":"10","author":"Hammoudeh M","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270510035017"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200401"},{"key":"e_1_2_1_7_2","first-page":"36","volume-title":"Atlas of standard radiographs in arthritis, Epidemiology of Chronic Rheumatism","author":"Kellgren JH","year":"1963"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270301"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_1_10_2","first-page":"854","article-title":"Radiological aspects of sacro\u2010iliac arthritis","volume":"50","author":"Grainger RG","year":"1957","journal-title":"Proc R Soc Med"},{"key":"e_1_2_1_11_2","unstructured":"Van der LindenSJ:Spondylitis Ankylopoetica: Een Familie en Bevolkingsonderzoek en toetsing van diagnostische Criteria (thesis). Leiden University (The Netherlands) 1982 pp105\u2013121"},{"key":"e_1_2_1_12_2","first-page":"121","article-title":"Le diagnostic precoce de la spondylarthrite ankylosante bases anatomo\u2010radiologiques","volume":"35","author":"Francois RJ","year":"1983","journal-title":"Rhumatologie"},{"key":"e_1_2_1_13_2","unstructured":"ShichikawaK TsujimotoM NishiokaJ NishibayashiY MatsumotoK:Histopathology of early sacroiliitis and enthesitis in ankylosing spondylitis The First Simmons Center International Symposium on the Spondyloarthropathies. Dallas TX May 31\u2010June 2 1984"},{"key":"e_1_2_1_14_2","first-page":"145","volume-title":"Diagnosis of ankylosing spondylitis, Progress in Clinical Rheumatology","author":"Khan MA","year":"1984"},{"key":"e_1_2_1_15_2","unstructured":"Van der LindenSJ ValkenburgH CatsA:Are women relatively protected from developing ankylosing spondylitis? The First Simmons Center International Symposium on the Spondyloarthropathies. Dallas TX May 31\u2010June 2 1984"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780280107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780280107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:33:49Z","timestamp":1700674429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780280107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/art.1780280107"],"URL":"https:\/\/doi.org\/10.1002\/art.1780280107","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}