{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:33:22Z","timestamp":1770982402355,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7577,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After observing a child with systemic onset juvenile rheumatoid arthritis (S\u2010JRA) who developed purpura fulminans in association with disseminated intravascular coagulation, with subsequent gangrene and autoamputation, we undertook a prospective study of coagulation parameters in children with JRA. Ten consecutive children with S\u2010JRA, 10 children with rheumatoid factor\u2010negative, polyarticular juvenile rheumatoid arthritis (P\u2010JRA), and 10 age\u2010 and sex\u2010matched controls were studied. Routine coagulation screening tests were performed, as were tests for plasma fibrinopeptide A (a sensitive measure of intravascular thrombin generation), factor VIII\u2010related antigen (an endothelial cell protein), and platelet factor 4 (a plateletsecreted protein). Our studies suggest that activation of intravascular coagulation is common in systemic onset JRA, but not in rheumatoid factor\u2010negative, polyarticular disease. The coagulopathy may cause severe morbidity. In addition, marked elevations of plasma factor VIII\u2010related antigen suggest perturbation of endothelial cells and vascular involvement in S\u2010JRA, but not in P\u2010JRA. Normal ranges of platelet factor 4 indicate that intravascular platelet consumption does not occur in either type of JRA, despite the thrombocytosis common in both.<\/jats:p>","DOI":"10.1002\/art.1780280304","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:03:37Z","timestamp":1171487017000},"page":"256-261","source":"Crossref","is-referenced-by-count":31,"title":["Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"28","author":[{"given":"J. Paul","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona C.","family":"Maryjowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"73","volume-title":"Juvenile Rheumatoid Arthritis","author":"Brewer EJ","year":"1982"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747709095457"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.2.129"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.2.138"},{"key":"e_1_2_1_6_2","first-page":"1113","volume-title":"Clinical Hematology","author":"Wintrobe MM","year":"1981"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260813"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80348-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90246-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106480"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107749"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(77)90025-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.1.66"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-2-183"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80704-5"},{"key":"e_1_2_1_16_2","first-page":"428","article-title":"Radioimmunoassay of the fibrinopeptides in relation to intravascular coagulation","volume":"293","author":"Nossel HL","year":"1976","journal-title":"N Engl J Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197702172960707"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107469"},{"key":"e_1_2_1_19_2","first-page":"112","article-title":"Immunofluorescent localization of factor VIII\u2010related antigen, fibrinogen and several other plasma proteins in hemostatic plugs in humans","volume":"87","author":"Sixma JJ","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.1.1.1"},{"key":"e_1_2_1_21_2","first-page":"312","article-title":"Predisposing factors to thrombosis in systemic lupus erythematosus: possible relation to endothelial cell damage","volume":"94","author":"Angles\u2010Cano E","year":"1979","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-4-482"},{"key":"e_1_2_1_23_2","first-page":"135A","article-title":"Evidence for activation of coagulation in Kawasaki syndrome (abstract)","volume":"17","author":"Burns JC","year":"1983","journal-title":"Pediatr Res"},{"key":"e_1_2_1_24_2","first-page":"369","article-title":"Platelet factor 4 levels in patients with coronary artery disease","volume":"97","author":"White GC","year":"1981","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V54.5.1192.1192","article-title":"Plasma B\u2010thromboglobulin: differentiation between intravascular and extravascular platelet destruction","volume":"54","author":"Han P","year":"1979","journal-title":"Blood"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780280304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780280304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:49:50Z","timestamp":1700689790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780280304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1002\/art.1780280304"],"URL":"https:\/\/doi.org\/10.1002\/art.1780280304","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}