{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:34:43Z","timestamp":1759484083765},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7546,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present in vitro study concerned the phagocytosis and intracellular killing by polymorphonuclear cells (PMN) of 5 patients with rheumatoid arthritis (RA) and 12 patients with Felty's syndrome (FS). PMN phagocytosis was assessed by microbiologic and morphologic methods, and intracellular killing was measured independently of continuous phagocytosis of viable bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic>). PMN from patients with RA or FS ingested <jats:italic>S aureus<\/jats:italic> opsonized with immunoglobulins and complement as effectively as did PMN from healthy donors. However, the capacity of patient PMN to ingest <jats:italic>S aureus<\/jats:italic> opsonized with sera lacking complement activity, e.g., heat\u2010inactivated donor serum and the sera of 2 patients with FS, was lower than that of healthy donor PMN. This decreased ingestion is associated with diminished expression of Fc receptors on the membrane of PMN from patients who have RA or FS. As with sera lacking complement activity, decreased capacity to ingest <jats:italic>S aureus<\/jats:italic> was observed after preloading donor PMN with immune aggregates, which also decreased the expression of Fc receptors. PMN from patients with RA or FS were found to be as active in killing <jats:italic>S aureus<\/jats:italic> as cells from healthy donors.<\/jats:p>","DOI":"10.1002\/art.1780280407","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:01:10Z","timestamp":1171486870000},"page":"395-404","source":"Crossref","is-referenced-by-count":18,"title":["Phagocytosis and intracellular killing by polymorphonuclear cells from patients with rheumatoid arthritis and felty's syndrome"],"prefix":"10.1002","volume":"28","author":[{"given":"Ferdinand C.","family":"Breedveld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Van den Barselaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C. J.","family":"Leijh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Cats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"van Furth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140119"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.4.359"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-3-381"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110302"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.5.486"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105372"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1969.tb02420.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107342"},{"key":"e_1_2_1_10_2","first-page":"183","article-title":"Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty's syndrome","volume":"88","author":"Gupta RC","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_2","first-page":"49","article-title":"Neutrophil function in rheumatoid arthritis","volume":"6","author":"Corberand J","year":"1977","journal-title":"Scand J Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210117"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","unstructured":"WiltonJMA GibsonT ChuckCM: Defective phagocytosis by synovial fluid and blood polymorphonuclear leukocytes in patients with rheumatoid arthritis. 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