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In 9 of these pre\u2010rheumatoid specimens, the Rose\u2010Waaler test result was positive, and in 16, the latex fixation test was positive. Two\u2010thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was &lt;4 years, and one\u2010third were positive when the interval was \u22674 years. 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