{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:56:52Z","timestamp":1700762212164},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":7529,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the T\u2013non\u2010T cell autologous mixed lymphocyte reaction (AMLR) of spleen cells from rats with arthritis induced by Freund's complete adjuvant in an effort to establish an animal model for the study of the relationship between the AMLR and autoimmune disease. We found that the splenic T\u2013non\u2010T AMLR was markedly decreased in rats with adjuvant\u2010induced arthritis and that this decrease was mediated by suppressor cells within the nylon\u2010wool\u2013adherent stimulator cell population. However, we also found a similar decrease in the AMLR of arthritis\u2010resistant Fisher 344 rats that received Freund's complete adjuvant but did not develop arthritis. Control animals with local inflammation induced by turpentine, a nonarthritogenic inflammatory substance, had normal AMLR, whereas other controls given Freund's incomplete adjuvant, also a nonarthritogenic substance, had a modest responder cell\u2013mediated decrease in AMLR. These studies help to clarify the relationship between the decreased AMLR and the pathogenesis of adjuvant\u2010induced arthritis by demonstrating that: 1 the acute\u2010phase inflammatory response does not reduce the AMLR; and 2 the decreased AMLR can occur in the absence of overt autoimmune disease. This latter observation calls into question the proposed pathogenetic relationship between the AMLR and autoimmune disease states.<\/jats:p>","DOI":"10.1002\/art.1780280512","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:58:10Z","timestamp":1171486690000},"page":"537-541","source":"Crossref","is-referenced-by-count":6,"title":["The autologous mixed lymphocyte reaction is decreased in Freund's adjuvant\u2013injected rats of arthritis\u2010susceptible and \u2010insusceptible strains"],"prefix":"10.1002","volume":"28","author":[{"given":"William E.","family":"Crowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack R.","family":"Battisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"515","volume-title":"Detection of self recognition cells by in vitro isogeneic lymphocyte interaction","author":"Howe ML","year":"1970"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.5.1327"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.5096"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(80)90285-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00699.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.7.3464"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.4049\/jimmunol.121.5.1889","article-title":"Syngeneic mixed lymphocyte reaction in mice: strain distribution, kinetics, participating cells, and absence in NZB mice","volume":"121","author":"Smith JB","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109960"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109982"},{"key":"e_1_2_1_11_2","first-page":"27","article-title":"Autologous and allogeneic reactivity in patients with rheumatoid arthritis","volume":"6","author":"Beck P","year":"1981","journal-title":"J Lab Clin Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-91-22179"},{"key":"e_1_2_1_13_2","first-page":"308","volume-title":"Arthritis in animals, Arthritis and Allied Conditions","author":"Pearson CM","year":"1979"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109940"},{"key":"e_1_2_1_15_2","first-page":"139","volume-title":"Immunological protocols can diminish or abrogate the expression of adjuvant arthritis, Immunoregulation and Autoimmunity","author":"Welles WL","year":"1980"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820138109051954"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251008"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197412000-00013"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780280512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780280512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:29:48Z","timestamp":1700699388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780280512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,5]]}},"alternative-id":["10.1002\/art.1780280512"],"URL":"https:\/\/doi.org\/10.1002\/art.1780280512","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,5]]}}}