{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:15Z","timestamp":1790873715748,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":7455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The diagnosis of neuropsychiatric systemic lupus erythematosus (NP\u2010SLE) is clinical and one of exclusion. Brain cross\u2010reactive lymphocytotoxins or neuronal antibodies have been proposed as a mechanism underlying NP\u2010SLE. We assessed the clinical relevance of neuronal cell binding antibodies using a standardized clinical definition of NP\u2010SLE. Serum from 54 SLE patients and 77 controls were tested for binding to 3 neuroblastoma and 3 glioblastoma cell lines. Thirty\u2010three SLE patients (61%) fulfilled clinical criteria for the diagnosis of NP\u2010SLE; of these, 55% had serum binding activity to both neuroblastoma and glioblastoma cell lines, compared with 33% of the other SLE patients. When reactivity to neuroblastoma cell lines only was assessed, 43% of NP\u2010SLE patient sera demonstrated binding activity, versus 14% of sera from the remaining SLE patients. Control subjects' reactivity to neuroblastoma cell lines was positive in 12% of sera. Analysis of serum reactivity using non\u2010neuronal cell lines revealed that neuroblastoma, but not glioblastoma, cell binding was specific. NP\u2010SLE patients with evidence of diffuse symptomatology had a higher mean titer of neuroblastoma cell line binding than those with focal symptomatology. Using a panel of substrates, one can identify a significant proportion of patients who are independently defined as having NP\u2010SLE, who demonstrate specific serum neuronal antibodies.<\/jats:p>","DOI":"10.1002\/art.1780280710","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:55:40Z","timestamp":1171486540000},"page":"789-795","source":"Crossref","is-referenced-by-count":127,"title":["Antineuronal antibodies in neuropsychiatric systemic lupus erythematosus"],"prefix":"10.1002","volume":"28","author":[{"given":"Angela","family":"How","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Dent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuen\u2010Kuei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judah A.","family":"Denburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"405","article-title":"Central nervous system lupus: diagnosis and treatment","volume":"7","author":"Hughes GRV","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(81)90100-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780221210"},{"key":"e_1_2_1_5_2","first-page":"333","article-title":"Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement","volume":"30","author":"Bresnihan B","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108303"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90016-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(83)90158-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220401"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220504"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90756-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250730"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91075-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_15_2","first-page":"1037","article-title":"Characterization of human malignant melanoma cell lines. 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