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This T1+ B cell population accounted for a mean of 19.6% (upper limit 48%) of the circulating B cells and did not correlate with clinical disease activity, rheumatoid factor, or drug treatment. The highest percentage of T1+ B cells found in the blood of 8 patients with connective tissue diseases, including systemic lupus erythematosus, was 5% of the B cells, and for normal controls, it was was 3% of the B cells. As previously reported, we confirmed that the T1+, Ig+ phenotype was a feature of leukemic cells in B\u2010type chronic lymphocytic leukemia. The finding of increased numbers of T1+ B cells in patients with rheumatoid arthritis and those with B\u2010type chronic lymphocytic leukemia raises the possibility that these cells play a role in a spectrum of diseases, including those involving autoimmunity and malignancy.<\/jats:p>","DOI":"10.1002\/art.1780280903","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T20:54:29Z","timestamp":1171486469000},"page":"971-976","source":"Crossref","is-referenced-by-count":185,"title":["A rheumatoid arthritis b cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"28","author":[{"given":"C.","family":"Plater\u2010Zyberk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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