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IgA\u2010RF expression correlated only weakly with IgM\u2010RF production (r = 0.385) and could be dissociated from production of IgA\u2010RF (and IgM\u2010RF) exhibited by simultaneously obtained peripheral blood plasma cells. While wide variations were observed in the ratio of IgA\u2010RF:IgM\u2010RF produced by synovial B cells in the patient sample studied, remarkable consistency in the relationship of IgA\u2010RF to IgM\u2010RF synthesis was observed overtime in different joints of the same patient. IgA\u2010RF synthesized by dissociated synovial cells was predominantly of the IgAl subclass and existed in both monomeric and polymeric forms. Our results are compatible with the view that local production of IgA\u2010RF and IgM\u2010RF are regulated independently of each other.<\/jats:p>","DOI":"10.1002\/art.1780281105","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:05:28Z","timestamp":1171487128000},"page":"1219-1227","source":"Crossref","is-referenced-by-count":30,"title":["IgA rheumatoid factor synthesis by dissociated synovial cells. Characterization and relationship to IgM rheumatoid factor synthesis"],"prefix":"10.1002","volume":"28","author":[{"given":"William J.","family":"Koopman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph E.","family":"Schrohenloher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia S.","family":"Crago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Spalding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Mestecky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1940.tb01475.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-68-16375"},{"key":"e_1_2_1_4_2","first-page":"217","volume-title":"Rheumatoid factor, Rheumatoid Arthritis","author":"Koopman WJ","year":"1985"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110402"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250208"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250911"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.105.5.425"},{"key":"e_1_2_1_9_2","first-page":"689","article-title":"Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels","volume":"6","author":"Winchester RJ","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110203"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105758"},{"key":"e_1_2_1_12_2","first-page":"204","article-title":"Local synthesis of IgM and IgM rheumatoid factor in rheumatoid pleuritis","volume":"10","author":"Halla JT","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270703"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280917"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105013"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130601"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230806"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(66)90276-X"},{"key":"e_1_2_1_19_2","first-page":"233","article-title":"Evidence for a common synthetic origin for secretory and serum IgA","volume":"45","author":"Abraham GN","year":"1974","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.2.161"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(82)90306-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110418"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.1.45"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.3.738"},{"key":"e_1_2_1_25_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_26_2","first-page":"888","article-title":"The latex fixation test. 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