{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:34:03Z","timestamp":1788582843550,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7303,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital complete heart block is closely associated with the presence of anti\u2010Ro (SS\u2010A) autoantibodies. Quantitative solid\u2010phase assays for Ro (SS\u2010A) autoantigen and autoantibody have established the presence of Ro (SS\u2010A) in cardiac tissues and have been used to evaluate an informative pedigree. The propositus we describe here had complete congenital heart block and showed anti\u2013Ro (SS\u2010A) binding of 13\u2010fold less than his normal HLA\u2010identical twin sister. Both had identical titers of antinuclear antibody. These data support the hypothesis that anti\u2013Ro (SS\u2010A) may be directly involved in the pathogenesis of congenital complete heart block.<\/jats:p>","DOI":"10.1002\/art.1780281202","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:05:08Z","timestamp":1171487108000},"page":"1321-1325","source":"Crossref","is-referenced-by-count":103,"title":["Ro (SS\u2010A) antibody and antigen in a patient with congenital complete heart block"],"prefix":"10.1002","volume":"28","author":[{"given":"John B.","family":"Harley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Kaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen F.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"467","article-title":"Sur une maladie infantile et familiale characteri\u00e9e par des modifications permanentes du pouls, des attaques syncopates et epileptiformes et al mort subite","volume":"4","author":"Morquio L","year":"1901","journal-title":"Arch Med Inf"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.6.648"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12482531"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70011-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307283090403"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111460"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.1996"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.102.1.117","article-title":"Characterization of soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythematosus","volume":"102","author":"Clark G","year":"1969","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","first-page":"309","article-title":"Anti\u2010La\/SSB antibody is present in some normal sera and is coincident with anti\u2010Ro\/SSA precipitins in systemic lupus erythematosus","volume":"11","author":"Harley JB","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","first-page":"35","volume-title":"Assays for antibodies against histocompatibility antigens, Handbook of Experimental Immunology","author":"Welsh K","year":"1978"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4049\/jimmunol.80.4.324","article-title":"Interaction of nuclei and globulin from lupus erythematosus serum demonstrated with fluorescent antibody","volume":"80","author":"Friou GF","year":"1958","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb29197.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250606"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198103000-00002"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120206"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-5-592"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302243080802"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(84)90246-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.6.1514"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.41.220.688"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6173.1235"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(71)90410-3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972203"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.46.1.104"}],"container-title":["Arthritis &amp; 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