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Mean leakage to the venous blood 3 hours after injection was 0.11% of the injected dose; this corresponds to a mean whole body dose of 0.2 rads. Mean leakage to the liver 24 hours after injection was 0.64% of the injected dose; this corresponds to a mean liver dose of 3.2 rads. In 7 additional patients examined, there was negligible or near negligible activity found in the draining inguinal lymph nodes. One\u2010year followup was possible for 74 knees (63 patients). Sixty\u2010one percent of the knees had good results, 23% had fair results, and 16% had poor results. There was a direct correlation between the radiographic stage and response to treatment. In knees with stage I radiographic changes, 72% showed good results; 93% showed improvement. In knees with stage II changes, 59% showed good results; 81% showed improvement. These preliminary results indicate that dysprosium 165\u2010ferric hydroxide macroaggregate is an effective agent for radiation synovectomy. The low leakage rates observed offer a definite advantage over agents previously used.<\/jats:p>","DOI":"10.1002\/art.1780290201","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:15:46Z","timestamp":1171487746000},"page":"153-159","source":"Crossref","is-referenced-by-count":56,"title":["Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165\u2010ferric hydroxide macroaggregates"],"prefix":"10.1002","volume":"29","author":[{"given":"Clement B.","family":"Sledge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Zalutsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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