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The patients with active disease, but not those with inactive disease, were found to have elevated numbers of cells spontaneously secreting immunoglobulin and a decreased B cell response to the T cell\u2010independent B cell mitogen, <jats:italic>Staphylococcus aureus<\/jats:italic> Cowan 1. Moreover, B cells from almost all patients with Beh\u00e7et's disease were unresponsive to the T cell\u2010dependent polyclonal activator, pokeweed mitogen. These results indicate that B cell abnormalities, including some which are associated with disease activity, could be involved in the pathogenesis of Beh\u00e7et's disease.<\/jats:p>","DOI":"10.1002\/art.1780290209","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:15:46Z","timestamp":1171487746000},"page":"212-219","source":"Crossref","is-referenced-by-count":42,"title":["Abnormal B cell function in patients with Beh\u00e7et's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Noboru","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Sakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokugoro","family":"Tsunematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-4-561"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5538.465"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1710970307"},{"key":"e_1_2_1_5_2","first-page":"193","article-title":"Circulating soluble immune complexes in recurrent oral ulceration and Beh\u00e7get's syndrome","volume":"32","author":"Levinsky RJ","year":"1978","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90461-3"},{"key":"e_1_2_1_7_2","first-page":"405","volume-title":"Serological studies on lymphocytotoxic antibodies and immune complexes in sera from patients with Beh\u00e7et's disease, Beh\u00e7et's Disease","author":"Suzuta T","year":"1982"},{"key":"e_1_2_1_8_2","first-page":"408","article-title":"Cell\u2010mediated immunity in uveitis. 3. 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