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Warfarin reduced urinary excretion of Gla in all patients, but no changes in calcium and phosphorus excretion or in objective parameters of calcinosis were observed during 6\u201336 months of treatment. Two patients experienced hemorrhagic complications during therapy, emphasizing a hazard of long\u2010term anticoagulation treatment. Since ectopic calcium deposits contain Gla\u2010rich protein, suppression of Gla synthesis by warfarin sodium over a longer period may prevent deposition and allow removal of existing calcinosis deposits.<\/jats:p>","DOI":"10.1002\/art.1780290306","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:14:04Z","timestamp":1171487644000},"page":"344-351","source":"Crossref","is-referenced-by-count":20,"title":["Effect of warfarin sodium therapy on excretion of 4\u2010carboxy\u2010L\u2010glutamic acid in scleroderma, dermatomyositis, and myositis ossificans progressiva"],"prefix":"10.1002","volume":"29","author":[{"given":"Sterling E.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien A.","family":"Jump","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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