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Rocket immunoelectrophoresis, using purified goat anti\u2010rat Fn, provided a specific and sensitive means of measuring plasma Fn in rats during the development of various inflammatory disease states. It was shown that normal rat plasma Fn levels of approximately 400 \u03bcg\/ml double within 24 hours after injection of adjuvant. Plasma Fn levels in this model of chronic systemic inflammatory joint disease were tracked for more than 4 months and remained significantly higher than normal. On the other hand, a carrageenan\u2010induced inflammatory response in the pleural cavity of rats resulted in a large local accumulation of leukocytes, but no change in plasma Fn levels. A carrageenan\u2010induced model of acute inflammation resulted in increased paw swelling within 6 hours and enhanced plasma Fn levels within 24 hours; plasma Fn levels returned to normal within 1 week. Quantitation of plasma Fn levels in the rat may provide a useful biochemical parameter for the study of chronic systemic inflammatory diseases.<\/jats:p>","DOI":"10.1002\/art.1780290313","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:14:04Z","timestamp":1171487644000},"page":"394-399","source":"Crossref","is-referenced-by-count":26,"title":["Fibronectin in acute and chronic inflammation"],"prefix":"10.1002","volume":"29","author":[{"given":"Vera J.","family":"Stecher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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