{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:21:18Z","timestamp":1762078878071},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7121,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>19S IgM rheumatoid factors (RF) may play an important role in sustaining inflammation in rheumatoid arthritis (RA). As yet, no unique antigenic specificity for RF in RA has been identified. Because the synovium is central to the pathogenic changes in RA, RF produced therein might be pathogenically more important than serum RF. Therefore, we examined the reactivity and relative avidity of 19S IgM\u2010RF in serum and rheumatoid synovial cells (RSC) from 20 patients with seropositive RA. Reactivities were determined by competitive inhibition of serum RF hemolytic activity and RSC RF\u2010plaque\u2010forming cells (PFC) by added soluble antigen, i.e., monomeric human IgG subclasses. Estimation of relative avidities of RSC RF for human IgG subclasses was done by calculation of fractional RF expression in the RSC RF\u2010PFC assay following inhibition by IgG subclasses. RSC RF had greatest reactivity with IgG3 and IgG1, some reactivity with IgG2, and the least reactivity with IgG4. Serum RF reacted most with IgG1 and IgG2, reacted some with IgG4, but reacted poorly with IgG3. The antigenic determinants with which RSC RF reacted were common to many IgG3 molecules. The highest relative avidity of RSC RF was for IgG3. These observations indicate a selective deficiency of serum RF compared with RSC RF and suggest an important pathogenic role for these qualitatively different RSC RF molecules for in situ RF immune complex\u2010mediated inflammation in RA synovial tissue.<\/jats:p>","DOI":"10.1002\/art.1780290604","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:10:20Z","timestamp":1171487420000},"page":"722-729","source":"Crossref","is-referenced-by-count":22,"title":["Estimation of the relative avidity of 19S IgM rheumatoid factor secreted by rheumatoid synovial cells for human IgG subclasses"],"prefix":"10.1002","volume":"29","author":[{"given":"Dick L.","family":"Robbins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Skilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Benisek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Richard","family":"Wistar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"677","volume-title":"Rheumatoid factor, Textbook of Rheumatology","author":"Carson DA","year":"1981"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108546"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(70)90220-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(76)90347-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(75)90116-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb43094.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572306"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.132.1.77"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210713"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(75)90073-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.4049\/jimmunol.122.3.980","article-title":"Relationship between antibody affinity and hemolytic plaque diameter. 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Purified anti\u2010DNP antibody","volume":"122","author":"Deheer DH","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(80)90019-X"},{"key":"e_1_2_1_14_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_15_2","first-page":"197","article-title":"Rheumatoid factor plaque\u2010forming cells in rheumatoid synovial tissue","volume":"28","author":"Taylor\u2010Upsahl MM","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_16_2","first-page":"437","article-title":"Comparative specificities of serum and synovial cell 19S IgM rheumatoid factors in rheumatoid arthritis","volume":"12","author":"Robbins DL","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4049\/jimmunol.119.1.295","article-title":"Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG","volume":"119","author":"Carson DA","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110424"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780290604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780290604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:03:13Z","timestamp":1700694193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780290604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1002\/art.1780290604"],"URL":"https:\/\/doi.org\/10.1002\/art.1780290604","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}