{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:31:04Z","timestamp":1790865064026,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7121,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Decreased numbers of complement receptor type 1 (CR1) have been observed on erythrocytes of patients with systemic lupus erythematosus (SLE) and on glomerular podocytes of patients having proliferative nephritis of SLE. In the present study, the analysis of the cellular expression of CR1 has been extended to include leukocytes. In addition, expression by B lymphocytes of the C3d receptor (CR2), which also serves as the receptor for the Epstein\u2010Barr virus, was assessed. Receptor expression was measured by 2\u2010color fluorescent flow cytometry of peripheral blood B cells, identified by the presence of the B1 antigen, that had also been stained with anti\u2010CR1 or anti\u2010CR2. B cells from 17 patients with SLE exhibited a mean relative fluorescence for CR1 that was 61% of that found in 17 normal individuals (<jats:italic>P<\/jats:italic> &lt; 0.001). The expression of CR2 by the patients' B cells (n = 14) was 62% of that of the B cells from normal subjects (n = 17) (<jats:italic>P<\/jats:italic> &lt; 0.001). The expression of CR1 correlated with that of CR2 among patients (r = 0.63; <jats:italic>P<\/jats:italic> &lt; 0.01) but not with the expression of CR2 among normal individuals (r = 0.36; <jats:italic>P<\/jats:italic> &gt; 0.1). The mean CR1 content of the patients' neutrophils was only 59% of the normal mean (<jats:italic>P<\/jats:italic> &lt; 0.001). Thus, abnormalities of complement receptor expression occur on the leukocytes of patients with SLE. These deficiencies may be secondary to interaction of the cells with the products of complement activation, or, in some individuals, the deficiencies may be familial.<\/jats:p>","DOI":"10.1002\/art.1780290606","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:10:20Z","timestamp":1171487420000},"page":"739-747","source":"Crossref","is-referenced-by-count":128,"title":["Decreased expression of the C3b\/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus"],"prefix":"10.1002","volume":"29","author":[{"given":"James G.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Ratnoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Schur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90882-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.5.1427"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210143071604"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260606"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271202"},{"key":"e_1_2_1_7_2","first-page":"547","article-title":"Family studies of erythrocyte complement receptor type 1 levels: reduced levels in patients with SLE are acquired, not inherited","volume":"59","author":"Walport MJ","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4049\/jimmunol.135.3.2005","article-title":"Disease\u2010associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and\/or complement activation","volume":"135","author":"Ross GD","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1698"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111018"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.3.691"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111944"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110764"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.1.20"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.131.2.684"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110529"},{"key":"e_1_2_1_17_2","first-page":"161","article-title":"Glomerular C3 receptor (abstract)","volume":"1","author":"Fischer E","year":"1984","journal-title":"Complement"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(83)90067-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1021"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.881"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4510"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.55.2.347-351.1985"},{"key":"e_1_2_1_23_2","first-page":"509","volume-title":"The B cell\u2010restricted glycoprotein B2 is the receptor for Epstein\u2010Barr virus, Leukocyte Typing II","author":"Nadler LM","year":"1986"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.5.1490"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_26_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.134.3.1851","article-title":"PM'A induces the ligand\u2010independent internalization of CR1 on human neutrophils","volume":"134","author":"Changelian PS","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.2.678"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)91322-0"},{"key":"e_1_2_1_30_2","first-page":"134","article-title":"Enzymatic digestion of rabbit gamma globulin and antibody and chromatography of digestion products","volume":"10","author":"Nisonoff A","year":"1964","journal-title":"Methods Med Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.4049\/jimmunol.126.5.1941","article-title":"Characterization of a human B cell\u2010specific antigen (B2) distinct from Bl","volume":"126","author":"Nadler LM","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_32_2","first-page":"31","article-title":"Isolation of leukocytes from human blood: further observations","volume":"21","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest [Suppl]"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.134.5.3332","article-title":"Characterization of a soluble form of the C3b\/C4b receptor (CR1) in human plasma","volume":"134","author":"Yoon SH","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90043-1"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(85)90362-X"},{"key":"e_1_2_1_36_2","first-page":"647","article-title":"Complement testing in the diagnosis of immune and autoimmune diseases","volume":"68","author":"Schur PH","year":"1977","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(80)90011-2"},{"key":"e_1_2_1_38_2","first-page":"108","article-title":"Detection and characterization of antibodies to nuclei, nuclear constituents, and nucleic acids by immunofluorescence and counterimmunoelectrophoresis","volume":"36","author":"Schur PH","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4049\/jimmunol.130.1.370","article-title":"Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures","volume":"130","author":"Fearon DT","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_40_2","first-page":"205","article-title":"Increased expression of the C3b receptor by neutrophils and complement activation during haemodialysis","volume":"56","author":"Lee J","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111572"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180305"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200312"},{"key":"e_1_2_1_44_2","first-page":"76","article-title":"Circulating and pokeweed mitogen\u2010induced immunoglobulin\u2010secreting cells in systemic lupus erythematosus","volume":"35","author":"Ginsburg WW","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_45_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.4049\/jimmunol.132.3.1197","article-title":"Immunoglobulin production by human peripheral lymphocytes induced by anti\u2010C3 receptor antibodies","volume":"132","author":"Daha MR","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150114"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.805"},{"key":"e_1_2_1_48_2","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.4049\/jimmunol.131.4.1797","article-title":"Epstein\u2010Barr virus induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus","volume":"131","author":"Tsokos GC","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.1.519"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60298-9"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.6.1615"},{"key":"e_1_2_1_52_2","first-page":"499","volume-title":"The C3d receptor identified by the HB\u20105 monoclonal antibody: expression and role as a receptor for Epstein\u2010Barr virus, Leukocyte Typing II","author":"Tedder TF","year":"1986"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111472"},{"key":"e_1_2_1_54_2","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.4049\/jimmunol.130.4.1668","article-title":"Expression of C3b receptors on human B cells and myelomonocytic cells but not natural killer cells","volume":"130","author":"Tedder TF","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190306"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197607000-00003"},{"key":"e_1_2_1_57_2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1001\/archinte.1978.03630360056023","article-title":"Familial systemic lupus erythematosus","volume":"138","author":"Buckman KJ","year":"1978","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.22.7711"},{"key":"e_1_2_1_59_2","first-page":"87","article-title":"Restriction fragment length polymorphism of the CR1 gene correlating with low number of CR1 on erythrocytes (E) (abstract)","volume":"2","author":"Wilson J","year":"1985","journal-title":"Complement"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780290606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780290606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:03:33Z","timestamp":1700694213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780290606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1002\/art.1780290606"],"URL":"https:\/\/doi.org\/10.1002\/art.1780290606","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}