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Twelve patients showed statistically significant improvement, as measured by the number of affected, swollen, tender, and functionally impaired joints, and by decreases in erythrocyte sedimentation rate and C\u2010reactive protein and an increase in hemoglobin level. Systemic manifestations improved in 6 of 8 patients. In 10 children receiving corticosteroids, the dosage was reduced. Seven patients did not respond to MTX therapy. Six of them showed an unchanged disease course, and 1 had a relapse after 4 months of MTX treatments. Probable side effects included gastrointestinal symptoms, elevated liver enzymes, and herpes zoster infection. MTX treatment should be considered for children with life\u2010threatening or severe disabling arthritis that is unresponsive to other therapy.<\/jats:p>","DOI":"10.1002\/art.1780290616","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:10:20Z","timestamp":1171487420000},"page":"801-807","source":"Crossref","is-referenced-by-count":59,"title":["Methotrexate therapy in juvenile rheumatoid arthritis: A retrospective study"],"prefix":"10.1002","volume":"29","author":[{"given":"H.","family":"Truckenbrodt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"H\u00e4fner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747209103011"},{"key":"e_1_2_1_3_2","first-page":"603","article-title":"Immunsuppressiva zur Basisbehandlung viszeraler Formen der kindlichen rheumatoiden Arthritis","volume":"67","author":"K\u00f6lle G","year":"1972","journal-title":"Med Klin"},{"key":"e_1_2_1_4_2","unstructured":"KvienTK H\u00f8yeraalHM SandstadB K\u00e5ssE:Azathioprine versus placebo in patients with juvenile rheumatoid arthritis: a double\u2010blind 16\u2010week clinical trial (abstract). 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