{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:32:09Z","timestamp":1761561129612},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7091,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies of methotrexate in the treatment of patients with rheumatoid arthritis have precluded patients with neutropenia. We present a patient with rheumatoid arthritis complicated by severe neutropenia and recurrent infections, who was treated with low\u2010dose methotrexate, orally, for 30 months. The patient experienced symptomatic improvement and a significant increase in granulocyte count, and the dosage of steroids was reduced. Low\u2010dose oral methotrexate may be a therapeutic option in select patients with Felty's syndrome.<\/jats:p>","DOI":"10.1002\/art.1780290713","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:21:54Z","timestamp":1171488114000},"page":"902-905","source":"Crossref","is-referenced-by-count":21,"title":["Treatment of Felty's syndrome with low\u2010dose oral methotrexate"],"prefix":"10.1002","volume":"29","author":[{"given":"Lisa Sherbin","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Groff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archinte.1978.03630280059020","article-title":"Splenectomy for Felty's syndrome","volume":"138","author":"Laszlo J","year":"1978","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.4.359"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198103053041005"},{"key":"e_1_2_1_5_2","first-page":"1108","article-title":"Letter to the editor","volume":"59","author":"Case DC","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90027-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","unstructured":"JaffeIA: Penicillamine: an anti\u2010rheumatoid drug.Am J Med63\u201368 1983","DOI":"10.1016\/0002-9343(83)90476-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197305102881906"},{"key":"e_1_2_1_9_2","first-page":"902","article-title":"Felty's syndrome: response to parenteral gold","volume":"8","author":"Luthra HS","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","first-page":"791","article-title":"Felty's syndrome: case report and rationale for disease\u2010suppressant immunosuppressive therapy","volume":"8","author":"Kaprove RE","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.235.20.2215"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(83)90014-8"},{"key":"e_1_2_1_14_2","first-page":"760","article-title":"A controlled two\u2010centre trial of parenteral methotrexate therapy for refractory rheumatoid arthritis","volume":"11","author":"Thompson RN","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-489"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780290713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780290713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T22:07:06Z","timestamp":1700690826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780290713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1002\/art.1780290713"],"URL":"https:\/\/doi.org\/10.1002\/art.1780290713","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}