{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:32:28Z","timestamp":1791322348929,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7029,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies have suggested that the induction of HLA\u2014DR antigens on epithelial cells plays an important role in the pathogenesis of autoimmune endocrine\u2010exocrine disorders. We found that salivary gland epithelial cells (i.e., acinar and ductal cells) in salivary gland biopsy specimens from patients with primary Sj\u00f6gren's syndrome (keratoconjunctivitis sicca) expressed high levels of HLA\u2014DR antigen, which were detected by staining frozen tissue sections with monoclonal antibodies and immunoperoxidase technique. In contrast, salivary gland epithelial cells from normal subjects did not express this antigen. Lymphocytes eluted from the salivary gland biopsy specimens of patients who had Sj\u00f6gren's syndrome produced a soluble factor that stimulated HLA\u2014DR synthesis by a salivary gland\u2010derived cell line (Sal\u20101). These tissue culture supernatants contained \u03b3\u2010interferon, and their ability to induce HLA\u2014DR synthesis was blocked by monoclonal anti\u2010\u03b3\u2010interferon antibody. These results demonstrate the presence of HLA\u2014DR antigen on salivary gland epithelial cells and suggest that local production of \u03b3\u2010interferon plays a role in this induction.<\/jats:p>","DOI":"10.1002\/art.1780290908","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:49:18Z","timestamp":1171489758000},"page":"1105-1111","source":"Crossref","is-referenced-by-count":94,"title":["Expression of histocompatibility antigen HLA\u2014DR by salivary gland epithelial cells in Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"29","author":[{"given":"Robert 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