{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:02:06Z","timestamp":1761742926246},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6968,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synovial fluid (SF) and synovial tissue from 10 patients with juvenile rheumatoid arthritis were examined. The SFs were heterogeneous with respect to the degree of complement activation. Quantification of C3dg and the terminal complement complex revealed a positive correlation between activation of the early and the late parts of the cascade in all patients. The amount of C\u2010reactive protein and the number of white blood cells in the SF correlated significantly with the degree of complement activation. Weak deposits of C3, C3dg, or terminal complement complex were observed in a few vessels in the synovial tissue from 5 of the patients. There was no correlation between complement activity in SF and in the corresponding tissue. Furthermore, there was no correlation between clinical activity in the joints and the degree of complement activation. It is concluded that there is a discrepancy between synovial tissue and synovial fluid with respect to complement activation. C\u2010reactive protein may, to some extent, be responsible for activation in SF, and the accumulation of white blood cells may be due to complement activation products.<\/jats:p>","DOI":"10.1002\/art.1780291108","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:17:25Z","timestamp":1171487845000},"page":"1359-1364","source":"Crossref","is-referenced-by-count":30,"title":["Complement activation in synovial fluid and tissue from patients with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"29","author":[{"given":"Tmo Eirik","family":"Mollnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"244","volume-title":"Human complement system, immunological Diseases","author":"Kohler PF","year":"1978"},{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/B978-0-12-635505-5.50010-X","volume-title":"Complement, The Antigens","author":"Lachmann PJ","year":"1979"},{"key":"e_1_2_1_3_2","first-page":"83","volume-title":"Plasma protein effectors of inflammation: complement, Textbook of Rheumatology","author":"Ruddy S","year":"1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(83)90006-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1984.tb00989.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01871.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1016\/S0021-9258(19)83603-7","article-title":"Isolation of human S\u2010protein, an inhibitor of the membrane attack complex of complement","volume":"254","author":"Podak ER","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000467856","article-title":"Early\u2010 and late\u2010phase activation of complement evaluated by plasma levels of C3dg and the terminal complement complex","volume":"2","author":"Mollnes TE","year":"1985","journal-title":"Complement"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290603"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748209098189"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2106\/00004623-196951040-00002","article-title":"Synovectomy and debridement of the knee in rheumatoid arthritis","volume":"51","author":"Geens S","year":"1969","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01851.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01870.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316474"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60299-0"},{"key":"e_1_2_1_16_2","first-page":"666","article-title":"Complement in the rheumatic diseases","volume":"22","author":"Schur PH","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_17_2","first-page":"391","article-title":"Association of rheumatoid factor with complement activation in rheumatoid arthritis and other diseases","volume":"53","author":"Reyes PA","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.132.4.673"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107949"},{"key":"e_1_2_1_20_2","first-page":"555","article-title":"Reduction of the complement activation capacity of soluble IgG aggregates and immune complexes by IgM\u2010rheumatoid factor","volume":"55","author":"Doekes G","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_21_2","first-page":"2135","article-title":"Interaction of C\u2010reactive protein complexes with the complement system. 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