{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:25:28Z","timestamp":1790112328147,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6968,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A number of viruses have been implicated as being the cause of various forms of myositis, including acute transient myositis, chronic polymyositis, and dermatomyositis. However, the cause of juvenile dermato\u2010myositis (JDM) has remained elusive. Our study of serum samples taken within 4 months of the onset of disease in 12 children with JDM showed that 83% had detectable titers of complement\u2010fixing (CF) antibody to 1 or more coxsackie B viral antigens. Detectable titers were found in only 25% of age\u2010, sex\u2010, and date\u2010matched control sera taken from 24 patients with juvenile rheumatoid arthritis (JRA), and in 25% of serum samples taken from 2,192 \u201cnormal\u201d children who had been hospitalized because of viral syndromes. Titers of CF antibody to coxsackie B1, B2, and B4 were positive in 58%, 50%, and 58%, respectively, of the JDM patients. In matched JRA controls, the respective values were 8%, 13%, and 8%. There were no significant antiviral titers and no significant differences in the results of tests for 13 other viral CF antigens, hepatitis B surface antigen, and <jats:italic>Mycoplasma pneumoniae<\/jats:italic> CF antigen in the JDM patient sera compared with the JRA patient sera. When titers of neutralizing antibody were determined, 58%, 58%, and 67% of the JDM patients were positive for coxsackie B2, B4, and B5, respectively, whereas 16%, 26%, and 21%, respectively, of the JRA controls were positive for the 3 antigens. These data suggest that the host response to coxsackie B virus might be related to the pathophysiology of JDM.<\/jats:p>","DOI":"10.1002\/art.1780291109","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:17:25Z","timestamp":1171487845000},"page":"1365-1370","source":"Crossref","is-referenced-by-count":162,"title":["PREVALENCE OF COXSACKIE B VIRUS ANTIBODIES IN PATIENTS WITH JUVENILE DERMATOMYOSITIS"],"prefix":"10.1002","volume":"29","author":[{"given":"MARY L.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Schneiderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendrakumar C.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.3.340"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490300103017"},{"key":"e_1_2_1_4_2","first-page":"255","article-title":"Acute myositis associated with influenza B infection","volume":"57","author":"Dietzman DE","year":"1976","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)91343-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.10.1323"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01641089"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000148970"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.1.33"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/jama.1978.03280300053021","article-title":"Hepatitis B antigen and polymyositis","volume":"239","author":"Mihas AA","year":"1978","journal-title":"JAMA"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.239.10.959"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92487-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180410"},{"key":"e_1_2_1_14_2","first-page":"474","volume-title":"Coxsackie viruses, Viral and Rickettsial Infections of Man","author":"Dalldorf G","year":"1965"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270411"},{"key":"e_1_2_1_16_2","first-page":"825A","article-title":"Live virus is required for induction of murine polymyositis by coxsackievirus B1 (abstract)","volume":"32","author":"Ytterberg SR","year":"1984","journal-title":"Clin Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80807-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90716-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb00371.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260216"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280208"},{"key":"e_1_2_1_22_2","first-page":"984A","article-title":"Antibody to coxsackie virus in juvenile dermatomyositis (abstract)","volume":"29","author":"Pachman LM","year":"1981","journal-title":"Clin Res"},{"key":"e_1_2_1_23_2","first-page":"S24","article-title":"Antibody to coxsackie\u2010B virus: increased incidence in sera from children with recently diagnosed juvenile dermatomyositis (abstract)","volume":"26","author":"Christensen ML","year":"1983","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_24_2","first-page":"1","volume-title":"Basic Laboratory Procedures in Diagnostic Virology","author":"Christensen ML","year":"1977"},{"key":"e_1_2_1_25_2","first-page":"471","volume-title":"Enteroviruses, Diagnostic Procedures for Viral, Rickettsial, and Chla\u2010mydial Infections","author":"Melnick JL","year":"1979"},{"key":"e_1_2_1_26_2","volume-title":"Statistical Methods for Rates and Proportions","author":"Fleiss JL","year":"1973"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00431.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108063050604"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.113.6.1726"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.2.239"}],"container-title":["Arthritis &amp; 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