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Staphylococci cocultured with cartilage increased release of proteoglycan 3\u20104\u2010fold within 48 hours. Viable cartilage was essential for maximum loss of proteoglycan. Killed bacteria had no effect on proteoglycan release. Four <jats:italic>Staphylococcus aureus<\/jats:italic> strains yielded growth media preparations active in proteoglycan release. Analysis of the proteoglycan subunits released from cartilage showed only limited degradation, and glycosaminoglycan chain length was not significantly altered.<\/jats:p>","DOI":"10.1002\/art.1780291111","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:17:25Z","timestamp":1171487845000},"page":"1378-1386","source":"Crossref","is-referenced-by-count":25,"title":["A staphylococcal proteoglycan\u2010releasing factor"],"prefix":"10.1002","volume":"29","author":[{"given":"R. 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