{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:51Z","timestamp":1762067151396},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6938,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood mononuclear cells from 20 healthy adults were tested in vitro for the production of IgM rheumatoid factor (RF) in response to <jats:italic>Staphylococcus aureus<\/jats:italic> Cowan I (SAC) or pokeweed mitogen. Fifteen of the 20 normal subjects produced \u2a7e4 ng\/ml IgM\u2010RF (mean \u00b1 SD 46 \u00b1 55 ng\/ml) in response to SAC, compared with only 2 of 20 who produced \u00b14 ng\/ml IgM\u2010RF (mean \u00b1 SD 2 \u00b1 4 ng\/ml) in response to pokeweed mitogen (<jats:italic>P<\/jats:italic> = 0.0001). Separation and reconstitution of autologous T and B cell\u2010enriched fractions, with and without prior T cell irradiation, provided evidence for a radiosensitive T helper\/inducer cell involved in the IgM\u2010RF response to SAC in 70% of the normal subjects studied. SAC appears to be a potent stimulus of IgM\u2010RF production, with a cellular mechanism distinct from that of other in vitro systems.<\/jats:p>","DOI":"10.1002\/art.1780291204","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:17:23Z","timestamp":1171487843000},"page":"1440-1445","source":"Crossref","is-referenced-by-count":10,"title":["In vitro synthesis of IgM rheumatoid factor in response to <i>STAPHYLOCOCCUS AUREUS<\/i>, by lymphocytes from healthy adults"],"prefix":"10.1002","volume":"29","author":[{"given":"Rose","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Karsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"541","volume-title":"Rheumatoid and seronegative arthritides, Immunology in Medicine","author":"Holborow EJ","year":"1977"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1429"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.4049\/jimmunol.125.2.934","article-title":"In vitro synthesis of IgM rheumatoid factor by lymphocytes from healthy adults","volume":"125","author":"Koopman WJ","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250912"},{"key":"e_1_2_1_5_2","first-page":"S82","article-title":"Staphylococcus aureus Cowan I is a potent stimulus of IgM rheumatoid factor production (abstract)","volume":"28","author":"Tar L","year":"1985","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_6_2","first-page":"557","volume-title":"Etiology and pathogenesis of rheumatoid arthritis, Arthritis and Allied Conditions","author":"Zvaifler NJ","year":"1985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/ajcp\/74.6.776","article-title":"Quantitative enzyme immunoassay for IgM rheumatoid factor using human immunoglobulin G as substrate","volume":"74","author":"Halbert SP","year":"1980","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-168-41284"},{"key":"e_1_2_1_9_2","first-page":"129","article-title":"Enzyme\u2010linked immunosorbent assay, ELISA. 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Quantitation of specific antibodies by enzyme\u2010labeled anti\u2010immunoglobulin in antigen\u2010coated tubes","volume":"109","author":"Engvall E","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.129.1.97","article-title":"Separate signals for human B cell proliferation and differentiation in response to Staphylococcus aureus: evidence for a two\u2010signal model of B cell activation","volume":"129","author":"Falkoff RJM","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1979.tb03278.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.122.4.1310","article-title":"Polyclonal immunoglobulin secretion by human B lymphocytes exposed to Epstein\u2010Barr virus in vitro","volume":"122","author":"Kirchner H","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1980.tb00037.x"},{"key":"e_1_2_1_14_2","first-page":"680","article-title":"Interaction between fibronectin, rheumatoid factor and aggregated gamma globulins","volume":"12","author":"Ferraccioli G","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90207-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4049\/jimmunol.130.1.162","article-title":"Two different rheumatoid factor\u2010producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators","volume":"130","author":"Fong S","year":"1983","journal-title":"J Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780291204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780291204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:29:46Z","timestamp":1700695786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780291204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1986,12]]}},"alternative-id":["10.1002\/art.1780291204"],"URL":"https:\/\/doi.org\/10.1002\/art.1780291204","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}