{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:52Z","timestamp":1760188852185},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6938,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ninety\u2010three serum and plasma samples from 45 patients with systemic lupus erythematosus were analyzed for the complex formed by Cls and its inhibitor, as well as for C3, C4, C4a desarginine, and staphylococcal protein A\u2010bound immune complexes. There were statistically significant correlations between Cls\u2010Cl inhibitor complex and CH50, between Cls\u2010Cl inhibitor complex and C4, and between Cls\u2010Cl inhibitor complex and C4a desarginine. Serial studies were performed on 24 patients over a period of 6 months. Seven of 21 patients with hypocomplementemia had persistently normal levels of Cls\u2010Cl inhibitor complex, 7 had transiently abnormal levels of Cls\u2010Cl inhibitor complex, and 7 had sustained abnormal levels of Cls\u2010Cl inhibitor complex. Two of 3 pregnant patients with normal levels of complement had abnormal levels of Cls\u2010Cl inhibitor complex. Staphylococcal protein A\u2010bound immune complexes demonstrated no correlation with any of the complement assays. Complement activation, as measured by Cls\u2010Cl inhibitor complex, is often a transient phenomenon in systemic lupus erythematosus patients with persistent hypocomplementemia.<\/jats:p>","DOI":"10.1002\/art.1780291207","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:17:23Z","timestamp":1171487843000},"page":"1467-1472","source":"Crossref","is-referenced-by-count":22,"title":["Hypocomplementemia with low Cls\u2010Cl inhibitor complex in systemic lupus erythematosus"],"prefix":"10.1002","volume":"29","author":[{"given":"M. D.","family":"Lockshin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasneem","family":"Qamar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Redecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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