{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:12:37Z","timestamp":1760217157782},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6876,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies of combinations of nonsteroidal drugs used in the treatment of rheumatoid arthritis (RA) have yielded conflicting results. We used standard methods to measure disease activity and high pressure liquid chromatography to measure plasma drug concentrations. We used doses of choline magnesium trisalicylate, adjusted to achieve therapeutic serum salicylate concentrations, and naproxen in a randomized, double\u2010blind, placebo\u2010controlled cross\u2010over study of full dose trisalicylate (CMT), full dose naproxen (N), full dose of both (CMT\u2010N), and half dose of both (cmt\u2010n) to examine their relative efficacy and toxicity in treating RA. CMT\u2010N was statistically superior to all other treatments in only 1 of 12 efficacy variables, but was equal to N and better than CMT or cmt\u2010n for 7 variables. There were minimal differences among treatments for the other 4 efficacy variables. The mean percentage difference for the efficacy variables between CMT\u2010N and N was 3%, between CMT\u2010N and CMT was 10.6%, and between CMT\u2010N and cmt\u2010n was 10.5%. Thirteen percent of patients manifested toxic reactions during the initial open dose\u2010adjustment salicylate run\u2010in phase. During the double\u2010blind phases of the study, CMT\u2010N was more toxic than N, CMT, or cmt\u2010n (7.5% versus 3.4%, 1.8%, and 3.7%, respectively). Tinnitus was more common when full\u2010dose CMT was used; N (N or CMT\u2010N) was associated with increased skin toxicity. Gastrointestinal complaints were equally common with all regimens. CMT\u2010N, although sometimes statistically superior to CMT, N, or cmt\u2010n, showed no clinically important additive or synergistic effect versus N or CMT alone.<\/jats:p>","DOI":"10.1002\/art.1780300204","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:40:08Z","timestamp":1171489208000},"page":"146-154","source":"Crossref","is-referenced-by-count":16,"title":["A controlled study of concurrent therapy with a nonacetylated salicylate and naproxen in rheumatoid arthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Daniel E.","family":"Furst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Blocka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney","family":"Cassell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Robert","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Hirschberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Josephson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Lachenbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Bruce","family":"Trimble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold E.","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(84)80017-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709108977"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976192224"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02505.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01062103"},{"key":"e_1_2_1_7_2","first-page":"397","article-title":"Pharmacokinetic and pharmcodynamic implications of long\u2010term administration of non\u2010steroidal anti\u2010inflammatory agents","volume":"15","author":"Muller FO","year":"1977","journal-title":"Int J Clin Pharmacol Res"},{"key":"e_1_2_1_8_2","first-page":"3218","article-title":"Ketoprofen\u2010aspirin interaction","volume":"59","author":"Paulotsky Y","year":"1983","journal-title":"Sem Hop Paris"},{"key":"e_1_2_1_9_2","first-page":"716","article-title":"The pharmacological properties of fenbufen: a review","volume":"30","author":"Slobuda AE","year":"1980","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974154374"},{"key":"e_1_2_1_11_2","first-page":"1","volume-title":"Diflunisal: chemistry, toxicology, experimental and human pharmacology. 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