{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:36:25Z","timestamp":1790847385389,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6876,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We reviewed the long\u2010term natural history of 21 adult\u2010onset Still's disease patients. Patient subsets were identified according to clinical course patterns. These included monocyclic systemic disease in 4, polycyclic systemic disease in 2, chronic articular monocyclic systemic disease in 10, and chronic articular polycyclic systemic disease in the remaining 5 patients. Functional outcome differed according to course patterns and the extent of articular involvement. Systemic manifestations, per se, did not contribute to poor functional prognosis. Chronic articular disease had the worst outcome: 27% evolved to functional class III status, compared with none in the cyclic systemic groups. Those patients who had a chronic articular pattern or a polyarticular onset and course were at higher risk to develop disabling arthritis. An aggressive approach to therapy, including the early use of remittive agents, should be considered in these patient subsets.<\/jats:p>","DOI":"10.1002\/art.1780300209","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:40:08Z","timestamp":1171471208000},"page":"186-194","source":"Crossref","is-referenced-by-count":282,"title":["Adult\u2010onset still's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"John J.","family":"Cush","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace C.","family":"Christy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Cooperstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.2.121"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00005792-197309000-00007","article-title":"Juvenile rheumatoid arthritis presenting in the adult as fever of unknown origin","volume":"52","author":"Bujak JS","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90201-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00007611-198005000-00005","article-title":"Acute febrile juvenile rheumatoid arthritis in adults: cause of polyarthritis and fever","volume":"73","author":"Goldman JA","journal-title":"South Med J"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241203"},{"key":"e_1_2_1_7_2","first-page":"758","article-title":"Still's arthritis in adults: disease or syndrome","volume":"10","author":"Del Paine DW","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198403000-00002"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250607"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_1_12_2","first-page":"789","article-title":"The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales","volume":"9","author":"Fries JF","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190216"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748309102900"},{"key":"e_1_2_1_15_2","first-page":"279","article-title":"Prognosis of juvenile rheumatoid arthritis","volume":"20","author":"Hanson V","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_16_2","first-page":"909","article-title":"Prognostic factors in juvenile chronic arthritis","volume":"9","author":"Dequeker J","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280415"},{"key":"e_1_2_1_19_2","first-page":"85","article-title":"Enfermedad de Still de inicio en la edad adulta","volume":"44","author":"Jimenez\u2010Balderas FJ","year":"1979","journal-title":"Prensa M\u00e9dica Mexicana"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.249.15.2065"},{"key":"e_1_2_1_21_2","first-page":"673","article-title":"Hepatic abnormalities in adult onset Still's disease","volume":"6","author":"Esdaile JM","year":"1979","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_2","first-page":"590","article-title":"Fifteen patients with adult onset Still's disease: life threatening liver failure in two (abstract)","volume":"22","author":"Baker DG","year":"1979","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_23_2","first-page":"833","article-title":"Amyloidosis in adult onset Still's disease","volume":"8","author":"Harrington TM","year":"1981","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; 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