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To compare clinical features of patients with and without airways dysfunction and to further test the hypothesis of a link between airways disease and exocrinopathy, we prospectively studied 2 groups of 15 lifetime nonsmoker female patients with seropositive rheumatoid arthritis (RA). The 2 groups were similar in their clinical and immunologic features, but differed in terms of airways function. Salivary, lacrimal, and sweat gland dysfunction were significantly more prevalent or severe in the group with airways disease. Antinuclear antibodies were also more prominent in the patients with airways disease, but antibodies against RNP, SS\u2010A, SS\u2010B, and double\u2010stranded DNA were not present in these patients. HLA\u2010DR4 was found in 80% of the RA patients with airways disease and in 57% of those without airways disease. HLA\u2013B8 and DR3 were equivalently distributed in both groups. This prospective study further documents the existence of small airways disease in RA and supports the view that autoimmune exocrinopathy predisposes to its expression.<\/jats:p>","DOI":"10.1002\/art.1780300302","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:40:02Z","timestamp":1171489202000},"page":"249-256","source":"Crossref","is-referenced-by-count":34,"title":["Airways disease in rheumatoid arthritis patients"],"prefix":"10.1002","volume":"30","author":[{"given":"V.","family":"Radoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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